进行性系统性硬化症患者血清和上清液中的可溶性白细胞介素-2受体、白细胞介素-2和白细胞介素-4
Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis.
作者信息
Famularo G, Procopio A, Giacomelli R, Danese C, Sacchetti S, Perego M A, Santoni A, Tonietti G
机构信息
Dipartimento di Medicina Sperimentale, University of L'Aquila, Italy.
出版信息
Clin Exp Immunol. 1990 Sep;81(3):368-72. doi: 10.1111/j.1365-2249.1990.tb05340.x.
Abstract
We studied the sera of patients with progressive systemic sclerosis (PSS) for elevated levels of soluble interleukin-2 receptor (sIL-2R), interleukin-2 (IL-2) and interleukin-4 (IL-4). We also measured IL-2, IL-4 and B cell growth factor (BCGF) activity in supernatants of peripheral blood mononuclear cells from the same patients. The finding of elevated serum sIL-2R and IL-2, and the increased levels of IL-2, IL-4 and BCGF activity in culture supernatants indicates that T lymphocyte hyperactivity likely play a major role in PSS. The failure to detect under our experimental conditions a direct proliferative effect of recombinant IL-2 on enriched normal B cells might suggest that IL-4 is the cytokine mainly responsible of the BCGF activity recovered in PSS supernatants.
摘要
我们研究了进行性系统性硬化症（PSS）患者血清中可溶性白细胞介素-2受体（sIL-2R）、白细胞介素-2（IL-2）和白细胞介素-4（IL-4）水平的升高情况。我们还检测了同一患者外周血单个核细胞培养上清液中的IL-2、IL-4和B细胞生长因子（BCGF）活性。血清sIL-2R和IL-2升高，以及培养上清液中IL-2、IL-4和BCGF活性水平增加，这一发现表明T淋巴细胞的过度活跃可能在PSS中起主要作用。在我们的实验条件下未能检测到重组IL-2对富集的正常B细胞的直接增殖作用，这可能表明IL-4是PSS上清液中恢复的BCGF活性的主要细胞因子。
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本文引用的文献
1
Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.系统性红斑狼疮患者培养淋巴细胞白细胞介素 -2 的产生及反应降低。
J Clin Invest. 1982 Jun;69(6):1388-92. doi: 10.1172/jci110579.
2
3
Interstitial lung disease in scleroderma. Analysis by bronchoalveolar lavage.硬皮病中的间质性肺疾病。经支气管肺泡灌洗分析
Arthritis Rheum. 1984 Nov;27(11):1254-62. doi: 10.1002/art.1780271107.
4
Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus.类风湿关节炎和系统性红斑狼疮中的白细胞介素2缺乏症。
Clin Immunol Immunopathol. 1984 Apr;31(1):109-17. doi: 10.1016/0090-1229(84)90195-8.
5
Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations.进行性系统性硬化症患者皮肤中的淋巴细胞。定量、亚型分析及临床相关性
Arthritis Rheum. 1984 Jun;27(6):645-53. doi: 10.1002/art.1780270607.
6
Scleroderma. A model for fibrosis.硬皮病。一种纤维化模型。
Arch Dermatol. 1983 Dec;119(12):957-62. doi: 10.1001/archderm.119.12.957.
7
Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).系统性红斑狼疮（SLE）患者白细胞介素1和白细胞介素2产生缺陷。
J Immunol. 1983 Jun;130(6):2651-5.
8
Expression of interleukin 2 receptors on activated human B cells.白细胞介素2受体在活化的人B淋巴细胞上的表达
J Exp Med. 1984 Nov 1;160(5):1450-66. doi: 10.1084/jem.160.5.1450.
9
Cellular immunity to collagen and laminin in scleroderma.硬皮病中针对胶原蛋白和层粘连蛋白的细胞免疫。
Arthritis Rheum. 1985 Jul;28(7):775-80. doi: 10.1002/art.1780280708.
10
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J Immunol. 1985 Nov;135(5):3172-7.
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