Famularo G, Procopio A, Giacomelli R, Danese C, Sacchetti S, Perego M A, Santoni A, Tonietti G
Dipartimento di Medicina Sperimentale, University of L'Aquila, Italy.
Clin Exp Immunol. 1990 Sep;81(3):368-72. doi: 10.1111/j.1365-2249.1990.tb05340.x.
We studied the sera of patients with progressive systemic sclerosis (PSS) for elevated levels of soluble interleukin-2 receptor (sIL-2R), interleukin-2 (IL-2) and interleukin-4 (IL-4). We also measured IL-2, IL-4 and B cell growth factor (BCGF) activity in supernatants of peripheral blood mononuclear cells from the same patients. The finding of elevated serum sIL-2R and IL-2, and the increased levels of IL-2, IL-4 and BCGF activity in culture supernatants indicates that T lymphocyte hyperactivity likely play a major role in PSS. The failure to detect under our experimental conditions a direct proliferative effect of recombinant IL-2 on enriched normal B cells might suggest that IL-4 is the cytokine mainly responsible of the BCGF activity recovered in PSS supernatants.
我们研究了进行性系统性硬化症（PSS）患者血清中可溶性白细胞介素-2受体（sIL-2R）、白细胞介素-2（IL-2）和白细胞介素-4（IL-4）水平的升高情况。我们还检测了同一患者外周血单个核细胞培养上清液中的IL-2、IL-4和B细胞生长因子（BCGF）活性。血清sIL-2R和IL-2升高，以及培养上清液中IL-2、IL-4和BCGF活性水平增加，这一发现表明T淋巴细胞的过度活跃可能在PSS中起主要作用。在我们的实验条件下未能检测到重组IL-2对富集的正常B细胞的直接增殖作用，这可能表明IL-4是PSS上清液中恢复的BCGF活性的主要细胞因子。
