Umlas J, Jacobson M, Kevy S V
Department of Pathology, Mount Auburn Hospital, Cambridge, Massachusetts.
Transfusion. 1991 Sep;31(7):648-9. doi: 10.1046/j.1537-2995.1991.31791368344.x.
To examine the appropriateness of the Food and Drug Administration's 10-year storage time for previously frozen red cells, 24-hour posttransfusion survival studies were performed, and the half-life of 3 units of autologous red cells that had been stored for 13.5, 14, and 17 years, respectively, was measured. The units had acceptable freeze-thaw-wash recovery (83.3-91.4%). When a 51Cr label was used for the previously frozen red cells and a simultaneous 52Cr label for freshly drawn autologous red cells was used as a comparison, it was seen that the previously frozen cells had normal 24-hour posttransfusion survival (75.1-88.4%) as well as normal half-life (23-33.7 days). These findings support further extension of the maximum allowable storage time for previously frozen red cells.
为检验美国食品药品监督管理局规定的先前冷冻红细胞10年储存时间是否合适，开展了输血后24小时存活研究，并测定了分别储存13.5年、14年和17年的3单位自体红细胞的半衰期。这些单位的冻融洗涤回收率可接受（83.3%-91.4%）。当对先前冷冻的红细胞使用51Cr标记，同时对新采集的自体红细胞使用52Cr标记作为对照时，发现先前冷冻的细胞输血后24小时存活正常（75.1%-88.4%），半衰期也正常（23-33.7天）。这些发现支持进一步延长先前冷冻红细胞的最大允许储存时间。
