Jacquemin Bénédicte, Sunyer Jordi, Forsberg Bertil, Aguilera Inmaculada, Briggs David, García-Esteban Raquel, Götschi Thomas, Heinrich Joachim, Järvholm Bengt, Jarvis Debbie, Vienneau Danielle, Künzli Nino
Centre for Research in Environmental Epidemiology, Barcelona, Spain.
Epidemiology. 2009 Jan;20(1):119-26. doi: 10.1097/EDE.0b013e3181886e76.
Few studies have investigated new onset of asthma in adults in relation to air pollution. The aim of this study is to investigate the association between modeled background levels of traffic-related air pollution at the subjects' home addresses and self-reported asthma incidence in a European adult population.
Adults from the European Respiratory Health Survey were included (n = 4185 from 17 cities). Subjects' home addresses were geocoded and linked to outdoor nitrogen dioxide (NO2) estimates, as a marker of local traffic-related pollution. We obtained this information from the 1-km background NO2 surface modeled in APMoSPHERE (Air Pollution Modelling for Support to Policy on Health and Environmental Risk in Europe). Asthma incidence was defined as reporting asthma in the follow-up (1999 to 2001) but not in the baseline (1991 to 1993).
A positive association was found between NO2 and asthma incidence (odds ratio 1.43; 95% confidence interval = 1.02 to 2.01) per 10 microg/m. Results were homogeneous among centers (P value for heterogeneity = 0.59).
We found an association between a marker of traffic-related air pollution and asthma incidence in European adults.
很少有研究调查成年人哮喘的新发情况与空气污染之间的关系。本研究的目的是调查在欧洲成年人群体中，根据受试者家庭住址模拟的与交通相关的空气污染背景水平与自我报告的哮喘发病率之间的关联。
纳入欧洲呼吸健康调查中的成年人（来自17个城市，共4185人）。对受试者的家庭住址进行地理编码，并与室外二氧化氮（NO₂）估计值相关联，将其作为当地与交通相关污染的一个指标。我们从APMoSPHERE（欧洲健康与环境风险政策支持空气污染模型）中模拟的1公里背景NO₂表面获取了这些信息。哮喘发病率定义为在随访期（1999年至2001年）报告患有哮喘，但在基线期（1991年至1993年）未报告。
发现每10微克/立方米的NO₂与哮喘发病率之间存在正相关（比值比1.43；95%置信区间 = 1.02至2.01）。各中心之间结果具有同质性（异质性P值 = 0.59）。
我们发现欧洲成年人中与交通相关的空气污染指标与哮喘发病率之间存在关联。
