Kuriyama Shinichi, Shimazu Taichi, Hozawa Atsushi, Kure Shigeo, Kurokawa Naoyuki, Kakizaki Masako, Sone Toshimasa, Matsuda-Ohmori Kaori, Nakaya Naoki, Satoh Hiroshi, Tsuji Ichiro
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
Metabolism. 2008 Nov;57(11):1570-5. doi: 10.1016/j.metabol.2008.06.013.
Controversy remains as to whether the presence of the tryptophan-to-arginine (Trp64Arg) variant of the beta(3)-adrenergic receptor gene impedes the magnitude of body weight loss by diet and exercise intervention. The objectives of the present study were to compare the changes in body weight between carriers and noncarriers of the Trp64Arg variant before and after 6 months of diet and exercise interventions for weight loss. A total of 37 middle-aged Japanese individuals (12 carriers and 25 noncarriers of the Trp64Arg variant) participated in the study. There were no significant differences in body weight between the 2 groups at the baseline. There were significant reductions in body weight both in carriers and noncarriers, but no significant differences between the 2 groups with respect to changes in these variables. The weight changes were -2.52 kg (95% confidence interval [CI], -3.56 to -1.48) among carriers and -1.89 kg (95% CI, -2.65 to -1.13) among noncarriers, and the change in the variant carrier group minus the change in the variant noncarrier group was -0.47 (95% CI, -1.97 to 1.02). These results suggest that the presence of the Trp64Arg variant of the beta(3)-adrenergic receptor gene may not play a major role as a hindrance to weight reduction.
β(3)-肾上腺素能受体基因的色氨酸-精氨酸（Trp64Arg）变体的存在是否会阻碍饮食和运动干预导致的体重减轻幅度，目前仍存在争议。本研究的目的是比较Trp64Arg变体携带者和非携带者在进行为期6个月的减肥饮食和运动干预前后的体重变化。共有37名日本中年个体（12名Trp64Arg变体携带者和25名非携带者）参与了该研究。两组在基线时的体重没有显著差异。携带者和非携带者的体重均显著降低，但两组在这些变量的变化方面没有显著差异。携带者的体重变化为-2.52 kg（95%置信区间[CI]，-3.56至-1.48），非携带者为-1.89 kg（95%CI，-2.65至-1.13），变体携带者组的变化减去变体非携带者组的变化为-0.47（95%CI，-1.97至1.02）。这些结果表明，β(3)-肾上腺素能受体基因的Trp64Arg变体的存在可能不会作为体重减轻的主要阻碍因素发挥作用。
