Pathogen-related oral spirochetes from dental plaque are invasive.
作者信息
Riviere G R, Weisz K S, Adams D F, Thomas D D
机构信息
Department of Pediatric Dentistry, School of Dentistry, Oregon Health Sciences University, Portland 97201.
出版信息
Infect Immun. 1991 Oct;59(10):3377-80. doi: 10.1128/iai.59.10.3377-3380.1991.
Abstract
Spirochetes that share pathogen-restricted antigens with Treponema pallidum subsp. pallidum have been identified in dental plaque and diseased gingival tissues, but it is not known whether these spirochetes possess virulence characteristics. In this study, plaque spirochetes were able to transmigrate a tissue barrier in vitro and were identified on the other side by using monoclonal antibodies specific for pathogen-restricted determinants from T. pallidum subsp. pallidum. This invasive capability is shared with T. pallidum subsp. pallidum, but cultured oral and intestinal treponemes did not perforate the tissue barrier. Cocultures indicated that invasive treponemes do not create opportunities for cultivable oral treponemes to cross the barrier. These findings indicate that gingival tissues may be a port of entry for previously unrecognized invasive spirochetes in humans.
摘要
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本文引用的文献
1
ELECTRON MICROSCOPIC OBSERVATIONS ON THE BACTERIAL FLORA OF ACUTE NECROTIZING ULCERATIVE GINGIVITIS.急性坏死性溃疡性龈炎细菌区系的电子显微镜观察
J Periodontol (1930). 1965 Jul-Aug;36:328-39. doi: 10.1902/jop.1965.36.4.328.
2
ELECTRON MICROSCOPY AS AN AID IN THE TAXONOMIC DIFFERENTIATION OF ORAL SPIROCHETES.电子显微镜在口腔螺旋体分类鉴别中的应用
Arch Oral Biol. 1965 Jan-Feb;10:127-38. doi: 10.1016/0003-9969(65)90064-6.
3
Host response to Treponema pallidum in intradermally-infected rabbits: evidence for persistence of infection at local and distant sites.皮内感染梅毒螺旋体的家兔的宿主反应：局部和远处部位存在持续性感染的证据。
J Invest Dermatol. 1980 Dec;75(6):470-5. doi: 10.1111/1523-1747.ep12524230.
4
Bacterial invasion of periodontal tissues in advanced periodontitis in humans.人类晚期牙周炎中细菌对牙周组织的侵袭。
J Periodontol. 1984 Oct;55(10):567-73. doi: 10.1902/jop.1984.55.10.567.
5
Acute necrotizing ulcerative gingivitis. A transmission electron microscope study.
J Periodontol. 1983 Nov;54(11):671-9. doi: 10.1902/jop.1983.54.11.671.
6
Scanning and transmission electron microscopic study of tissue-invading microorganisms in localized juvenile periodontitis.
J Periodontol. 1983 Oct;54(10):598-617. doi: 10.1902/jop.1983.54.10.598.
7
Intracellular location of Treponema pallidum (Nichols strain) in the rabbit testis.梅毒螺旋体（Nichols株）在兔睾丸中的细胞内定位。
Infect Immun. 1971 Sep;4(3):307-14. doi: 10.1128/iai.4.3.307-314.1971.
8
An electron microscopic study of a syphilitic chancre. Engulfment of Treponema pallidum by plasma cells.梅毒初疮的电子显微镜研究。浆细胞对梅毒螺旋体的吞噬作用。
Arch Pathol. 1970 Aug;90(2):143-50.
9
Serial ultrathin sectioning demonstrating the intracellularity of T. Pallidum. An electron microscopic study.连续超薄切片显示梅毒螺旋体的细胞内存在情况。一项电子显微镜研究。
Br J Vener Dis. 1972 Apr;48(2):87-96. doi: 10.1136/sti.48.2.87.
10
Adherence of oral treponemes and their effect on morphological damage and detachment of epithelial cells in vitro.
Infect Immun. 1986 Feb;51(2):642-7. doi: 10.1128/iai.51.2.642-647.1986.
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