衰老、氧化应激与癌症：视差中的范式
Ageing, oxidative stress and cancer: paradigms in parallax.
作者信息
Benz Christopher C, Yau Christina
机构信息
Christopher C. Benz and Christina Yau are at the Buck Institute for Age Research, Novato, California 94945, USA.
出版信息
Nat Rev Cancer. 2008 Nov;8(11):875-9. doi: 10.1038/nrc2522.
Abstract
Two paradigms central to geroscience research are that aging is associated with increased oxidative stress and increased cancer risk. Therefore, it could be deduced that cancers arising with ageing will show evidence of increased oxidative stress. Recent studies of gene expression in age-controlled breast cancer cases indicate that this deduction is false, posing parallax views of these two paradigms, and highlighting the unanswered question: does ageing cause or simply permit cancer development?
摘要
老年科学研究的两个核心范式是，衰老与氧化应激增加以及癌症风险增加相关。因此，可以推断，随着年龄增长而出现的癌症将显示出氧化应激增加的证据。最近对年龄匹配的乳腺癌病例进行的基因表达研究表明，这一推断是错误的，这对这两个范式提出了不同的观点，并突出了一个尚未解决的问题：衰老是导致癌症发生还是仅仅允许癌症发展？
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本文引用的文献
1
Puzzles, promises and a cure for ageing.
Nature. 2008 Aug 28;454(7208):1065-71. doi: 10.1038/nature07216.
2
Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers.
Breast Cancer Res. 2008;10(4):R61. doi: 10.1186/bcr2120. Epub 2008 Jul 17.
3
Cancer suppression at old age.
Cancer Res. 2008 Jun 1;68(11):4465-78. doi: 10.1158/0008-5472.CAN-07-1670.
4
The mitochondrial free radical theory of ageing--where do we stand?
Front Biosci. 2008 May 1;13:6554-79. doi: 10.2741/3174.
5
Are cancer and ageing different sides of the same coin? Conference on Cancer and Ageing.
EMBO Rep. 2008 Mar;9(3):234-8. doi: 10.1038/embor.2008.12. Epub 2008 Feb 8.
6
Impact of aging on the biology of breast cancer.
Crit Rev Oncol Hematol. 2008 Apr;66(1):65-74. doi: 10.1016/j.critrevonc.2007.09.001. Epub 2007 Oct 18.
7
The ageing mitochondrial genome.
Nucleic Acids Res. 2007;35(22):7399-405. doi: 10.1093/nar/gkm635. Epub 2007 Oct 2.
8
Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers.
Breast Cancer Res. 2007;9(5):R59. doi: 10.1186/bcr1765.
9
Cellular senescence: when bad things happen to good cells.
Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40. doi: 10.1038/nrm2233.
10
Trends in oxidative aging theories.
Free Radic Biol Med. 2007 Aug 15;43(4):477-503. doi: 10.1016/j.freeradbiomed.2007.03.034. Epub 2007 Apr 10.
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