Mancebo Maria C, Grant Jon E, Pinto Anthony, Eisen Jane L, Rasmussen Steven A
Butler Hospital, Providence, RI 02906, USA.
J Anxiety Disord. 2009 May;23(4):429-35. doi: 10.1016/j.janxdis.2008.08.008. Epub 2008 Sep 6.
The prevalence and clinical correlates of substance use disorders (SUDs) were examined in a clinical sample of Obsessive Compulsive Disorder (OCD). As part of their intake interview into an observational study of the course of OCD, 323 participants completed a battery of standardized measures. Twenty-seven percent of the sample met lifetime criteria for a SUD. 70% of participants with comorbid SUDs reported that OCD preceded SUD onset by at least one year. Younger age at OCD onset and presence of Borderline Personality Disorder (BPD) were each associated with increased risk of alcohol use disorders but only BPD was associated with increased risk of drug use disorders. SUDs affect more than one-quarter of individuals who seek treatment for OCD. Individuals with a juvenile-onset of OCD or comorbid BPD may be especially vulnerable to SUDs. Further research is needed to identify risk factors for SUDs and to better understand their impact on OCD course.
在强迫症（OCD）的临床样本中，对物质使用障碍（SUDs）的患病率及其临床关联因素进行了研究。作为对强迫症病程进行观察性研究的入组访谈的一部分，323名参与者完成了一系列标准化测量。27%的样本符合SUD的终身标准。70%患有共病SUD的参与者报告称，强迫症在SUD发病前至少一年就已出现。强迫症发病时年龄较小以及存在边缘性人格障碍（BPD）均与酒精使用障碍风险增加相关，但只有BPD与药物使用障碍风险增加相关。SUDs影响了超过四分之一寻求强迫症治疗的个体。患有青少年期起病的强迫症或共病BPD的个体可能尤其容易患上SUDs。需要进一步研究以确定SUDs的风险因素，并更好地了解它们对强迫症病程的影响。
