Tsolis Renée M, Young Glenn M, Solnick Jay V, Bäumler Andreas J
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, 95616 California, USA.
Nat Rev Microbiol. 2008 Dec;6(12):883-92. doi: 10.1038/nrmicro2012. Epub 2008 Oct 28.
Bacterial enteric infections are often associated with diarrhoea or vomiting, which are clinical presentations commonly referred to as gastroenteritis. However, some enteric pathogens, including typhoidal Salmonella serotypes, Brucella species and enteropathogenic Yersinia species are associated with a clinical syndrome that is characterized by abdominal pain and/or fever and is distinct from acute gastroenteritis. Recent insights into molecular mechanisms of the host-pathogen interaction show that these enteric pathogens share important characteristics that explain why the initial host responses associated with these agents more closely resemble host responses to viral or parasitic infections. Host responses contribute to the clinical presentation of disease and improved understanding of these responses in the laboratory is beginning to bridge the gap between bench and bedside.
细菌性肠道感染常伴有腹泻或呕吐，这些临床表现通常被称为肠胃炎。然而，一些肠道病原体，包括伤寒沙门氏菌血清型、布鲁氏菌属和肠道致病性耶尔森菌属，与一种以腹痛和/或发热为特征的临床综合征有关，且与急性肠胃炎不同。最近对宿主-病原体相互作用分子机制的深入了解表明，这些肠道病原体具有重要的共同特征，这解释了为什么与这些病原体相关的初始宿主反应更类似于宿主对病毒或寄生虫感染的反应。宿主反应导致了疾病的临床表现，在实验室中对这些反应的更好理解正开始弥合基础研究与临床应用之间的差距。
