Cull Charley, Singu Vijay K, Cull Brooke J, Lechtenberg Kelly F, Amachawadi Raghavendra G, Schutz Jennifer S, Bryan Keith A
Midwest Veterinary Services, Inc., Oakland, NE 68045, USA.
Central States Research Centre, Inc., Oakland, NE 68045, USA.
Antibiotics (Basel). 2022 Sep 29;11(10):1328. doi: 10.3390/antibiotics11101328.
Salmonella enterica, which causes typhoid fever, is one of the most prevalent food-borne pathogens. Salmonellosis in cattle can greatly impact a producer’s income due to treatment costs, decreased productivity of the herd, and mortality due to disease. Current methods of treatment and prevention for salmonellosis consist of antibiotics and vaccinations, but neither of these options are perfect. Probiotics, categorized as antibiotic alternatives, are living microorganisms that are added to animal feeds in appropriate quantities in order to benefit health and productivity in adult and newborn livestock. The objective of this study was to demonstrate that Lactobacillus animalis and Propionibacterium freudenreichii, when used as a direct-fed microbial, was effective in reducing the adverse effects of experimentally induced Salmonella infection in beef calves. We conducted a single site efficacy study with masking using a randomized design comprising two groups of ten beef calves allocated to two treatment groups (control and probiotic). Procedures such as determining general health scores and body weight and collecting fecal samples were carried out following the experimental challenge of calves with Salmonella Typhimurium. The presence of at least one CFU of bacteria in feces was significantly higher among animals in the control than in the probiotic group, which was higher on days 0 to 7 than on days 8 to 14 (p = 0.012). Animals in the control group had a significantly higher presence of abnormal diarrhea scores than animals in the probiotic group (p < 0.001). Most notably, other health benefits in probiotic-fed group calves were obviously better than those for control calves and further substantiates the potential economic and health benefits of feeding effective probiotics.
引起伤寒热的肠炎沙门氏菌是最常见的食源性病原体之一。牛的沙门氏菌病会因治疗成本、牛群生产力下降以及疾病导致的死亡率而极大地影响生产者的收入。目前治疗和预防沙门氏菌病的方法包括使用抗生素和疫苗接种，但这两种方法都并非完美无缺。益生菌被归类为抗生素替代品，是适量添加到动物饲料中的活微生物，旨在促进成年和新生家畜的健康和生产力。本研究的目的是证明动物乳杆菌和费氏丙酸杆菌作为直接投喂微生物，在减轻实验诱导的肉牛犊沙门氏菌感染的不良影响方面是有效的。我们进行了一项单地点有效性研究，采用随机设计并设盲，包括两组，每组十头肉牛犊，分配到两个处理组（对照组和益生菌组）。在用鼠伤寒沙门氏菌对犊牛进行实验性攻毒后，进行了诸如确定一般健康评分和体重以及收集粪便样本等程序。对照组动物粪便中至少有一个菌落形成单位（CFU）细菌的情况明显高于益生菌组，在第0至7天高于第8至14天（p = 0.012）。对照组动物异常腹泻评分的出现情况明显高于益生菌组动物（p < 0.001）。最值得注意的是，益生菌喂养组犊牛的其他健康益处明显优于对照组犊牛，这进一步证实了投喂有效益生菌的潜在经济和健康益处。
