Lee Sun-Young, Shin Yong Woon, Hahm Ki-Baik
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
J Dig Dis. 2008 Aug;9(3):129-39. doi: 10.1111/j.1751-2980.2008.00334.x.
Helicobacter pylori (H. pylori) infection causes peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphomas and gastric adenocarcinomas, for which the pathogenesis of chronic gastric inflammation prevails and provides the pathogenic basis. Since the role of H. pylori infection is promoting carcinogenesis rather than acting as a direct carcinogen, as several publications show, eradication alone cannot be the right answer for preventing H. pylori-associated gastric cancer. Therefore, a non-antimicrobial approach has been suggested to attain microbe-associated cancer prevention through controlling H. pylori-related chronic inflammatory processes and mediators responsible for carcinogenesis. Phytoceutical is a term for plant products that are active on biological systems. Phytoceuticals such as Korean red ginseng, green tea, red wine, flavonoids, broccoli sprouts, garlic, probiotics and flavonoids are known to inhibit H. pylori colonization, decrease gastric inflammation by inhibiting cytokine and chemokine release, and repress precancerous changes by inhibiting nuclear factor-kappa B DNA binding, inducing profuse levels of apoptosis and inhibiting mutagenesis. Even though further unsolved issues are awaited before phytoceuticals are accepted as a standard treatment for H. pylori infection, phytoceuticals can be a mighty weapon for either suppressing or modulating the disease-associated footprints of H. pylori infection.
幽门螺杆菌（H. pylori）感染会引发消化性溃疡疾病、黏膜相关淋巴组织（MALT）淋巴瘤和胃腺癌，慢性胃炎症的发病机制在其中占主导地位并提供了致病基础。正如一些出版物所表明的，由于幽门螺杆菌感染的作用是促进致癌作用而非直接充当致癌物，仅根除幽门螺杆菌并不能成为预防幽门螺杆菌相关胃癌的正确答案。因此，有人提出一种非抗菌方法，通过控制与幽门螺杆菌相关的慢性炎症过程和负责致癌作用的介质来实现与微生物相关的癌症预防。植物药是指对生物系统有活性的植物产品。已知诸如韩国红参、绿茶、红酒、类黄酮、西兰花芽、大蒜、益生菌和类黄酮等植物药可抑制幽门螺杆菌定植，通过抑制细胞因子和趋化因子释放来减轻胃部炎症，并通过抑制核因子-κB DNA结合、诱导大量细胞凋亡和抑制诱变来抑制癌前病变。尽管在植物药被接受为幽门螺杆菌感染的标准治疗方法之前还有一些未解决的问题，但植物药可以成为抑制或调节幽门螺杆菌感染相关疾病痕迹的有力武器。
