从蛙分枝杆菌中分离得到的 mycolactone E 的合成与结构。
Synthesis and structure of mycolactone E isolated from frog mycobacterium.
机构信息
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
出版信息
Org Lett. 2008 Dec 4;10(23):5385-8. doi: 10.1021/ol802233f.
Abstract
The structure of mycolactone E, isolated from the frog pathogen Mycobacterium liflandii, was established via organic synthesis. Within the mycolactone family of metabolites, a structural variation has been seen only at the unsaturated fatty acid moiety thus far, and mycolactone E follows this observation. Interestingly, the absolute configuration of its unsaturated fatty acid matches that of the mycolactones from human mycobacteria, rather than the structurally more closely related mycolactone F from fish mycobacteria.
摘要
从蛙病原体利福霉素分枝杆菌中分离出的埃博霉素 E 的结构是通过有机合成确定的。在埃博霉素类代谢产物中，到目前为止只在不饱和脂肪酸部分观察到结构变化，埃博霉素 E 也符合这一观察结果。有趣的是，其不饱和脂肪酸的绝对构型与来自人类分枝杆菌的埃博霉素一致，而不是与来自鱼类分枝杆菌的结构上更为相似的埃博霉素 F。
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