一种通过生物合成工程获得的新型分枝杆菌内酯毒素。 - Suppr

Suppr

超能文献

A novel mycolactone toxin obtained by biosynthetic engineering.

作者信息

Hong Hui, Stinear Tim, Porter Jessica, Demangel Caroline, Leadlay Peter F

机构信息

Sanger Building, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1QW, UK.

出版信息

Chembiochem. 2007 Nov 23;8(17):2043-7. doi: 10.1002/cbic.200700411.

DOI:10.1002/cbic.200700411

PMID:17907121

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2699038/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e4/2699038/04894bd70091/cbic0008-2043-f5.jpg

相似文献

A novel mycolactone toxin obtained by biosynthetic engineering.一种通过生物合成工程获得的新型分枝杆菌内酯毒素。

Chembiochem. 2007 Nov 23;8(17):2043-7. doi: 10.1002/cbic.200700411.

Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.利用液相色谱-质谱联用技术（LC-MSn）对溃疡分枝杆菌临床分离株生物合成聚酮类毒素分枝杆菌内酯过程中的共代谢物进行鉴定。

Chem Commun (Camb). 2003 Nov 21(22):2822-3. doi: 10.1039/b308163j.

Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.解析产分枝杆菌内酯的分枝杆菌中聚酮化合物变异的遗传基础。

BMC Genomics. 2008 Oct 7;9:462. doi: 10.1186/1471-2164-9-462.

Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.黏帚菌素通过改变早期信号转导和翻译后事件来抑制 T 细胞的反应性。

J Immunol. 2010 Feb 1;184(3):1436-44. doi: 10.4049/jimmunol.0902854. Epub 2009 Dec 30.

Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins.分枝杆菌内酯的合成变体结合并激活威斯科特-奥尔德里奇综合征蛋白。

J Med Chem. 2014 Sep 11;57(17):7382-95. doi: 10.1021/jm5008819. Epub 2014 Sep 2.

Suspension cultivation of Mycobacterium ulcerans for the production of mycolactones.用于生产分枝杆菌内酯的溃疡分枝杆菌悬浮培养。

FEMS Microbiol Lett. 2001 Dec 18;205(2):385-9. doi: 10.1111/j.1574-6968.2001.tb10977.x.

A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.从溃疡分枝杆菌临床分离株中获得的一种新型分枝杆菌内酯，为模块化聚酮合酶的特定变化导致毒素异质性增加提供了证据。

Chembiochem. 2005 Apr;6(4):643-8. doi: 10.1002/cbic.200400339.

Chemistry of mycolactones, the causative toxins of Buruli ulcer.分枝杆菌酸的化学结构，导致了布鲁里溃疡的发病原因。

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6703-8. doi: 10.1073/pnas.1015252108. Epub 2011 Mar 7.

Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue.检测分枝杆菌溃疡感染人体组织中的马兜铃酸 A/B。

PLoS Negl Trop Dis. 2010 Jan 5;4(1):e577. doi: 10.1371/journal.pntd.0000577.

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone.溃疡分枝杆菌毒素分枝杆菌内酯对树突状细胞功能的选择性抑制

J Exp Med. 2007 Jun 11;204(6):1395-403. doi: 10.1084/jem.20070234. Epub 2007 May 21.

引用本文的文献

A rapid and simple MALDI-TOF MS lipid profiling method for differentiating from .一种用于与……区分的快速简便的基质辅助激光解吸电离飞行时间质谱脂质谱分析方法。（注：原文中“differentiating from...”后缺少具体内容）

J Clin Microbiol. 2025 Mar 12;63(3):e0140024. doi: 10.1128/jcm.01400-24. Epub 2025 Jan 27.

Exploring Mycolactone-The Unique Causative Toxin of Buruli Ulcer: Biosynthetic, Synthetic Pathways, Biomarker for Diagnosis, and Therapeutic Potential.探索分枝杆菌内酯——布鲁里溃疡的独特致病毒素：生物合成、合成途径、诊断生物标志物及治疗潜力

Toxins (Basel). 2024 Dec 6;16(12):528. doi: 10.3390/toxins16120528.

A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain.人体布鲁里溃疡模型：人为感染控制的案例和选择溃疡分枝杆菌挑战株的考虑因素。

PLoS Negl Trop Dis. 2023 Jun 29;17(6):e0011394. doi: 10.1371/journal.pntd.0011394. eCollection 2023 Jun.

From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone.从细菌毒素到治疗剂：类鼻疽酮的意外命运。

Toxins (Basel). 2023 May 30;15(6):369. doi: 10.3390/toxins15060369.

Mycolactone Purification from M. ulcerans Cultures and HPLC-Based Approaches for Mycolactone Quantification in Biological Samples.从溃疡分枝杆菌培养物中提取莫洛内酯及基于 HPLC 的生物样本中莫洛内酯定量分析方法。

Methods Mol Biol. 2022;2387:117-130. doi: 10.1007/978-1-0716-1779-3_13.

Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls.米卡链霉菌酮能否激发新型强效镇痛药？前景与挑战。

Toxins (Basel). 2019 Sep 4;11(9):516. doi: 10.3390/toxins11090516.

Buruli Ulcer, a Prototype for Ecosystem-Related Infection, Caused by Mycobacterium ulcerans.布鲁里溃疡，一种由溃疡分枝杆菌引起的与生态系统相关感染的原型。

Clin Microbiol Rev. 2017 Dec 13;31(1). doi: 10.1128/CMR.00045-17. Print 2018 Jan.

The chemistry and biology of mycolactones.分枝杆菌内酯的化学与生物学

Beilstein J Org Chem. 2017 Aug 11;13:1596-1660. doi: 10.3762/bjoc.13.159. eCollection 2017.

Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans.分枝杆菌溃疡分枝杆菌大环内酯外毒素(mycolactone)的构效关系研究。

PLoS Negl Trop Dis. 2013;7(3):e2143. doi: 10.1371/journal.pntd.0002143. Epub 2013 Mar 28.

Highly stereoselective total synthesis of fully hydroxy-protected mycolactones A and B and their stereoisomerization upon deprotection.高度对映选择性全合成完全羟基保护的麦迪霉素 A 和 B 及其去保护后的立体异构化。

Chemistry. 2011 Apr 4;17(15):4118-30. doi: 10.1002/chem.201002627. Epub 2011 Mar 15.

本文引用的文献

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone.溃疡分枝杆菌毒素分枝杆菌内酯对树突状细胞功能的选择性抑制

J Exp Med. 2007 Jun 11;204(6):1395-403. doi: 10.1084/jem.20070234. Epub 2007 May 21.

Evolution of Mycobacterium ulcerans and other mycolactone-producing mycobacteria from a common Mycobacterium marinum progenitor.溃疡分枝杆菌及其他产分枝杆菌内酯的分枝杆菌从共同的海分枝杆菌祖先进化而来。

J Bacteriol. 2007 Mar;189(5):2021-9. doi: 10.1128/JB.01442-06. Epub 2006 Dec 15.

Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F.全球分布的分枝杆菌属鱼类病原体产生一种新的质粒编码毒性大环内酯类物质——分支杆菌内酯F。

Infect Immun. 2006 Nov;74(11):6037-45. doi: 10.1128/IAI.00970-06. Epub 2006 Aug 21.

Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.利用质谱法对来自青蛙病原体分枝杆菌属MU128FXT的新型霉菌毒素家族进行结构解析。

Chem Commun (Camb). 2005 Sep 14(34):4306-8. doi: 10.1039/b506835e. Epub 2005 Aug 5.

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin.溃疡分枝杆菌短暂胞内阶段对宿主免疫反应的调节：内源性分枝杆菌内酯毒素的作用

Cell Microbiol. 2005 Aug;7(8):1187-96. doi: 10.1111/j.1462-5822.2005.00546.x.

A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin.从患有致命感染的非洲爪蟾属物种的实验室菌落中分离出的一种新发现的分枝杆菌病原体产生了一种新型的分枝杆菌内酯，即溃疡分枝杆菌大环内酯毒素。

Infect Immun. 2005 Jun;73(6):3307-12. doi: 10.1128/IAI.73.6.3307-3312.2005.

Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control.布氏杆菌溃疡（溃疡分枝杆菌感染）：新见解，疾病控制新希望。

PLoS Med. 2005 Apr;2(4):e108. doi: 10.1371/journal.pmed.0020108. Epub 2005 Apr 26.

Chembiochem. 2005 Apr;6(4):643-8. doi: 10.1002/cbic.200400339.

Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans.在地理分布多样的溃疡分枝杆菌菌株中发现的不稳定毒力质粒pMUM的共同进化起源。

J Bacteriol. 2005 Mar;187(5):1668-76. doi: 10.1128/JB.187.5.1668-1676.2005.

Structure determination of mycolactone C via total synthesis.通过全合成确定分枝杆菌内酯C的结构。

Org Lett. 2004 Dec 23;6(26):4901-4. doi: 10.1021/ol0479996.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验