Karelin Alexander A, Tsvetkov Yury E, Paulovicová Lucia, Bystrický Slavomír, Paulovicová Ema, Nifantiev Nikolay E
Laboratory of Glycoconjugate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russia.
Carbohydr Res. 2009 Jan 5;344(1):29-35. doi: 10.1016/j.carres.2008.09.016. Epub 2008 Sep 24.
The 3-aminopropyl glycoside of a heptasaccharide fragment of the cell wall mannan from Candida guilliermondii 18, which corresponds to the antigenic Factor 9, has been synthesized by a convergent approach based on glycosylation of a tetrasaccharide acceptor with a trisaccharide donor as the key step to give a protected heptasaccharide 17. Subsequent two-step deprotection of 17 afforded the heptamannoside 18, which was then conjugated with BSA using the squarate procedure.
季也蒙念珠菌18细胞壁甘露聚糖七糖片段的3-氨基丙基糖苷，其对应于抗原因子9，已通过一种汇聚法合成，该方法以四糖受体与三糖供体的糖基化为关键步骤，得到受保护的七糖17。随后对17进行两步脱保护得到七甘露糖苷18，然后使用方酸法将其与牛血清白蛋白偶联。
