Bainey Kevin R, Jugdutt Bodh I
Division of Cardiology, Department of Medicine, Faculty of Medicine, University of Alberta, Edmonton, Canada.
Atherosclerosis. 2009 May;204(1):1-10. doi: 10.1016/j.atherosclerosis.2008.09.023. Epub 2008 Oct 1.
Despite improvements in cardiovascular outcomes, coronary artery disease (CAD) continues to be a major cause of death worldwide. South-Asians (SAs) show an increased risk of atherosclerosis and have the highest mortality rates from CAD than any other ethnic group. The greater susceptibility of SAs to CAD cannot be explained entirely by conventional risk factors alone. Other factors are involved, such as genetic predisposition and high prevalence of the metabolic syndrome and type-2 diabetes. CAD is more severe, extensive and malignant among SAs. It is often unsuspected and associated with adverse outcome requiring a more aggressive management strategy. With the growing SA population in North America, physicians need to be aware of the epidemiology, conventional causes, associated contributors, and adverse outcomes of CAD in this group. Importantly, physicians need a structured approach and an aggressive management algorithm for the optimal care of the high-risk SA patient population.
尽管心血管疾病的治疗效果有所改善，但冠状动脉疾病（CAD）仍是全球主要的死亡原因。南亚人（SAs）患动脉粥样硬化的风险增加，且CAD死亡率高于其他任何种族。南亚人对CAD的易感性增加不能完全由传统风险因素来解释。还涉及其他因素，如遗传易感性、代谢综合征和2型糖尿病的高患病率。CAD在南亚人中更为严重、广泛且恶性程度更高。它常常未被察觉，且与不良后果相关，需要更积极的管理策略。随着北美南亚人口的不断增加，医生需要了解该群体中CAD的流行病学、传统病因、相关因素和不良后果。重要的是，医生需要一种结构化的方法和积极的管理算法，以对高危南亚患者群体进行最佳治疗。
