Das A, Ambale-Venkatesh B, Lima J A C, Freedman J E, Spahillari A, Das R, Das S, Shah R V, Murthy V L
Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Department of Medicine and Cardiology, Heart and Vascular Institute, Johns Hopkins Medical Institutions, The Johns Hopkins University, Baltimore, USA.
Nutr Metab Cardiovasc Dis. 2017 Jan;27(1):32-40. doi: 10.1016/j.numecd.2016.08.001. Epub 2016 Aug 6.
Cardiovascular disease (CVD) is one of the main causes of mortality and morbidity worldwide. As an emerging population, South Asians (SAs) bear a disproportionately high burden of CVD relative to underlying classical risk factors, partly attributable to a greater prevalence of insulin resistance and diabetes and distinct genetic and epigenetic influences. While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA). In this review, we describe the current literature on prevalence, prognosis and CVD risk in SAs, and provide a landscape of translational research in this field toward ameliorating CVD risk in SAs.
心血管疾病（CVD）是全球死亡和发病的主要原因之一。作为一个新兴群体，南亚人（SAs）相对于潜在的经典风险因素而言，承担着不成比例的高心血管疾病负担，部分原因是胰岛素抵抗和糖尿病的患病率较高，以及独特的遗传和表观遗传影响。虽然南亚人与其他种族在心血管疾病风险方面的表型差异越来越明显，但这些疾病的生物学机制仍是一个活跃的研究领域，新出现的研究涉及代谢、基因变异和表观遗传修饰因子（如细胞外RNA）。在这篇综述中，我们描述了关于南亚人心血管疾病患病率、预后和风险的当前文献，并提供了该领域旨在改善南亚人心血管疾病风险的转化研究概况。
