• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在 9.4 和 16.4T 下进行 17O NMR 灵敏度的体外和体内研究。

In vitro and in vivo studies of 17O NMR sensitivity at 9.4 and 16.4 T.

机构信息

Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.

出版信息

Magn Reson Med. 2013 Jun;69(6):1523-7. doi: 10.1002/mrm.24386. Epub 2012 Jul 6.

DOI:10.1002/mrm.24386
PMID:22777729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3470764/
Abstract

In vivo 17O magnetic resonance spectroscopy has been successfully applied for imaging the cerebral metabolic rate of oxygen consumption through the detection of metabolically produced H2(17)O from the inhaled 17O-labeled oxygen in animals at high field. In this study, we compared the 17O sensitivity for detecting natural abundance H2(17)O signals from a phantom solution and rat brains at 9.4 and 16.4 T. The 17O signal-to-noise ratio measured at 16.4 T was 2.9- and 2.7-2.8-fold higher than that at 9.4 T for the phantom and rat brain studies, respectively. Similarly, three-dimensional 17O magnetic resonance spectroscopy imaging data showed a more than 2.7-fold higher signal-to-noise ratio in the central rat brain region at 16.4 T than that at 9.4 T. The substantial 17O signal-to-noise ratio gain at ultrahigh field significantly improved the reliability for imaging the cerebral metabolic rate of oxygen consumption and will provide an opportunity for in vivo assessment of altered oxidative metabolism associated with brain functions and neurological diseases.

摘要

在体 17O 磁共振波谱已成功应用于通过检测动物吸入的 17O 标记氧代谢产生的 H2(17)O，对脑氧代谢率进行成像。在这项研究中，我们比较了在 9.4 和 16.4 T 下，对来自模型溶液和大鼠脑的天然丰度 H2(17)O 信号的 17O 灵敏度。在 16.4 T 下测量的 17O 信噪比分别比在 9.4 T 下的模型溶液和大鼠脑研究高 2.9-和 2.7-2.8 倍。同样，三维 17O 磁共振波谱成像数据显示，在 16.4 T 下，大鼠脑中心区域的信噪比比在 9.4 T 下高 2.7 倍以上。超高场下的 17O 信号与噪声比的显著提高显著提高了对脑氧代谢率成像的可靠性，并将为与脑功能和神经疾病相关的氧化代谢变化的体内评估提供机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/f350b8ba6850/nihms383377f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/e3ef87b84b9a/nihms383377f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/5be1cd3c939f/nihms383377f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/876b548b8b6f/nihms383377f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/f350b8ba6850/nihms383377f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/e3ef87b84b9a/nihms383377f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/5be1cd3c939f/nihms383377f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/876b548b8b6f/nihms383377f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3f4/3470764/f350b8ba6850/nihms383377f4.jpg

相似文献

1
In vitro and in vivo studies of 17O NMR sensitivity at 9.4 and 16.4 T.在 9.4 和 16.4T 下进行 17O NMR 灵敏度的体外和体内研究。
Magn Reson Med. 2013 Jun;69(6):1523-7. doi: 10.1002/mrm.24386. Epub 2012 Jul 6.
2
In vivo 17O NMR approaches for brain study at high field.用于高场脑研究的体内17O核磁共振方法。
NMR Biomed. 2005 Apr;18(2):83-103. doi: 10.1002/nbm.930.
3
Determination of the rate of cerebral oxygen consumption and regional cerebral blood flow by non-invasive 17O in vivo NMR spectroscopy and magnetic resonance imaging. Part 2. Determination of CMRO2 for the rat by 17O NMR, and CMRO2, rCBF and the partition coefficient for the cat by 17O MRI.通过非侵入性体内17O核磁共振波谱和磁共振成像测定脑氧消耗率和局部脑血流量。第2部分。用17O核磁共振测定大鼠的脑氧代谢率，用17O磁共振成像测定猫的脑氧代谢率、局部脑血流量和分配系数。
Neurol Res. 1993 Feb;15(1):7-22. doi: 10.1080/01616412.1993.11740100.
4
In vivo measurement of CBF using ¹⁷O NMR signal of metabolically produced H₂¹⁷O as a perfusion tracer.利用代谢产生的 H₂¹⁷O 的 ¹⁷O NMR 信号作为示踪剂进行 CBF 的体内测量。
Magn Reson Med. 2013 Aug;70(2):309-14. doi: 10.1002/mrm.24469. Epub 2012 Sep 21.
5
In vivo oxygen-17 nuclear magnetic resonance for the estimation of cerebral blood flow and oxygen consumption.用于估计脑血流量和氧消耗的体内氧-17核磁共振
Biochem Biophys Res Commun. 1991 Sep 16;179(2):954-61. doi: 10.1016/0006-291x(91)91911-u.
6
Determination of regional cerebral oxygen consumption in the human: 17O natural abundance cerebral magnetic resonance imaging and spectroscopy in a whole body system.人体局部脑氧消耗的测定：全身系统中的17O自然丰度脑磁共振成像与波谱分析
Neurol Res. 1993 Aug;15(4):237-48. doi: 10.1080/01616412.1993.11740143.
7
Quantitative 17O imaging towards oxygen consumption study in tumor bearing mice at 7 T.在 7T 下对荷瘤小鼠进行氧消耗研究的定量 17O 成像。
Magn Reson Imaging. 2013 Jun;31(5):643-50. doi: 10.1016/j.mri.2012.10.009. Epub 2013 Jan 5.
8
In vivo measurement of cerebral oxygen consumption and blood flow using 17O magnetic resonance imaging.使用17O磁共振成像技术对大脑氧消耗和血流进行体内测量。
Magn Reson Med. 1991 Oct;21(2):313-9. doi: 10.1002/mrm.1910210217.
9
Simplified methods for calculating cerebral metabolic rate of oxygen based on 17O magnetic resonance spectroscopic imaging measurement during a short 17O2 inhalation.基于短时间吸入17O2期间的17O磁共振波谱成像测量来计算脑氧代谢率的简化方法。
J Cereb Blood Flow Metab. 2004 Aug;24(8):840-8. doi: 10.1097/01.WCB.0000125885.54676.82.
10
17O relaxation time and NMR sensitivity of cerebral water and their field dependence.脑水的17O弛豫时间和核磁共振灵敏度及其场依赖性。
Magn Reson Med. 2001 Apr;45(4):543-9. doi: 10.1002/mrm.1073.

引用本文的文献

1
Quantitative O MRSI of myocardial oxygen metabolic rate, blood flow, and oxygen extraction fraction under normal and high workload conditions.定量 O MRSI 检测在正常和高工作负荷条件下的心肌氧代谢率、血流和氧摄取分数。
Magn Reson Med. 2024 Apr;91(4):1645-1658. doi: 10.1002/mrm.29908. Epub 2023 Dec 12.
2
Magnetic Resonance Water Tracer Imaging Using 17 O-Labeled Water.使用¹⁷O标记水的磁共振水示踪成像
Invest Radiol. 2024 Jan 1;59(1):92-103. doi: 10.1097/RLI.0000000000001021. Epub 2023 Sep 15.
3
Quantification of regional CMRO in human brain using dynamic O-MRI at 3T.

本文引用的文献

1
The signal-to-noise ratio of the nuclear magnetic resonance experiment. 1976.核磁共振实验的信噪比。1976年。
J Magn Reson. 2011 Dec;213(2):329-43. doi: 10.1016/j.jmr.2011.09.018.
2
In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field.用于在高场下成像脑氧代谢的体内氧-17核磁共振技术。
Prog Nucl Magn Reson Spectrosc. 2011 Nov;59(4):319-35. doi: 10.1016/j.pnmrs.2011.04.002. Epub 2011 Apr 23.
3
Cardiac 17O MRI: toward direct quantification of myocardial oxygen consumption.心脏 17O MRI：直接定量心肌耗氧量的方法。
使用3T动态氧增强磁共振成像对人脑局部脑代谢率进行定量分析。
Z Med Phys. 2025 Feb;35(1):46-58. doi: 10.1016/j.zemedi.2023.07.004. Epub 2023 Aug 8.
4
Neuroimaging Methods to Map In Vivo Changes of OXPHOS and Oxidative Stress in Neurodegenerative Disorders.神经退行性疾病中氧化磷酸化和氧化应激的体内变化的神经影像学方法。
Int J Mol Sci. 2022 Jun 30;23(13):7263. doi: 10.3390/ijms23137263.
5
Imaging Extracellular Acidification and Immune Activation in Cancer.癌症中细胞外酸化与免疫激活的成像
Curr Opin Biomed Eng. 2021 Jun;18. doi: 10.1016/j.cobme.2021.100278. Epub 2021 Mar 5.
6
A dual-tuned O/ H head array for direct brain oximetry at 3 Tesla.用于3特斯拉直接脑血氧饱和度测量的双调谐O/H头部阵列。
Magn Reson Med. 2020 Apr;83(4):1512-1518. doi: 10.1002/mrm.28005. Epub 2019 Oct 8.
7
X-Nuclear MRS Imaging Methods for Quantitative Assessment of Neuroenergetic Biomarkers in Studying Brain Function and Aging.用于定量评估神经能量生物标志物以研究脑功能和衰老的X核磁共振波谱成像方法。
Front Aging Neurosci. 2018 Nov 27;10:394. doi: 10.3389/fnagi.2018.00394. eCollection 2018.
8
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo.基于磁共振成像的氘代谢成像（DMI）进行体内代谢的 3D 图谱绘制。
Sci Adv. 2018 Aug 22;4(8):eaat7314. doi: 10.1126/sciadv.aat7314. eCollection 2018 Aug.
9
Quantitative imaging of brain energy metabolisms and neuroenergetics using in vivo X-nuclear H, O and P MRS at ultra-high field.超高场体内 X 核 H、O 和 P MRS 对脑能量代谢和神经能量学的定量成像。
J Magn Reson. 2018 Jul;292:155-170. doi: 10.1016/j.jmr.2018.05.005.
10
In vivoO MRS imaging - Quantitative assessment of regional oxygen consumption and perfusion rates in living brain.活体磁共振波谱成像——对活体大脑区域氧消耗和灌注率的定量评估。
Anal Biochem. 2017 Jul 15;529:171-178. doi: 10.1016/j.ab.2016.08.026. Epub 2016 Aug 26.
Magn Reson Med. 2010 Jun;63(6):1442-7. doi: 10.1002/mrm.22382.
4
Radionuclide imaging of myocardial metabolism.心肌代谢的放射性核素成像。
Circ Cardiovasc Imaging. 2010 Mar;3(2):211-22. doi: 10.1161/CIRCIMAGING.109.860593.
5
Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4 T.在 9.4T 人体大脑中使用 17 氧和 23 钠磁共振成像对脑组织质量校正的脑氧代谢率生物标度进行映射的可行性。
Neuroimage. 2010 Jun;51(2):723-33. doi: 10.1016/j.neuroimage.2010.02.056. Epub 2010 Feb 24.
6
Estimation of the regional cerebral metabolic rate of oxygen consumption with proton detected 17O MRI during precision 17O2 inhalation in swine.在猪精确吸入17O2期间，用质子检测的17O磁共振成像估算局部脑氧代谢率。
J Neurosci Methods. 2009 Apr 30;179(1):29-39. doi: 10.1016/j.jneumeth.2009.01.008. Epub 2009 Jan 20.
7
Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study.9.4T 下大鼠脑代谢率（CMRO₂）的无创三维成像：重复性测试及正常体温/低温比较研究
J Cereb Blood Flow Metab. 2007 Jun;27(6):1225-34. doi: 10.1038/sj.jcbfm.9600421. Epub 2006 Nov 29.
8
In vivo 17O NMR approaches for brain study at high field.用于高场脑研究的体内17O核磁共振方法。
NMR Biomed. 2005 Apr;18(2):83-103. doi: 10.1002/nbm.930.
9
Simplified methods for calculating cerebral metabolic rate of oxygen based on 17O magnetic resonance spectroscopic imaging measurement during a short 17O2 inhalation.基于短时间吸入17O2期间的17O磁共振波谱成像测量来计算脑氧代谢率的简化方法。
J Cereb Blood Flow Metab. 2004 Aug;24(8):840-8. doi: 10.1097/01.WCB.0000125885.54676.82.
10
Proton MRI of metabolically produced H2 17O using an efficient 17O2 delivery system.使用高效的17O2输送系统对代谢产生的H2 17O进行质子磁共振成像。
Neuroimage. 2004 Jun;22(2):611-8. doi: 10.1016/j.neuroimage.2004.02.024.