Zell Roland, Bergmann Silke, Krumbholz Andi, Wutzler Peter, Dürrwald Ralf
Institut für Virologie und Antivirale Therapie, Universitätsklinikum, Friedrich Schiller Universität, Hans-Knöll-Str. 2, 07745, Jena, Germany.
Arch Virol. 2008;153(11):2085-92. doi: 10.1007/s00705-008-0244-1. Epub 2008 Nov 6.
A novel H3N2 influenza virus strain isolated in Germany from pigs with clinical symptoms of influenza is described. It was characterised by neutralisation test, hemagglutination inhibition test and complete sequencing of the genome. The data demonstrate the emergence of a H3N2 reassortant with the human-like HAH3 gene of prevalent European porcine H3N2 influenza viruses and a NAN2 gene of the European porcine H1N2 viruses. The gene segments of the internal proteins are avian-like, consistent with European porcine influenza viruses. Analysis of GenBank sequence data reveals numerous reassortment events in recent years, demonstrating ongoing evolution of swine influenza viruses.
本文描述了在德国从出现流感临床症状的猪身上分离出的一种新型H3N2流感病毒株。通过中和试验、血凝抑制试验和基因组全序列分析对其进行了特性鉴定。数据表明，出现了一种H3N2重配病毒，其具有流行的欧洲猪H3N2流感病毒的类人HAH3基因和欧洲猪H1N2病毒的NAN2基因。内部蛋白的基因片段类似禽类，这与欧洲猪流感病毒一致。对GenBank序列数据的分析揭示了近年来发生的大量重配事件，表明猪流感病毒在持续进化。
