Wheeler G D, Singh M, Pierce W D, Epling W F, Cumming D C
Department of Physical Education, University of Alberta, Edmonton, Canada.
J Clin Endocrinol Metab. 1991 Feb;72(2):422-5. doi: 10.1210/jcem-72-2-422.
Cross-sectional studies have suggested that total and bioavailable testosterone levels are reduced in some male athletes. Such changes may be related to loss of body weight, increased serum cortisol, and/or alterations in LH pulsatile release. To determine how endurance training may affect androgen levels, we measured serum total testosterone, sex hormone-binding globulin, free androgen index, LH, FSH, PRL, cortisol, and weight in 15 previously sedentary males. We also examined pulsatile LH release in a subset of 5 subjects. Over 6 months of training, the men increased weekly running mileage to an average of 56 km/week. Total testosterone and free androgen index levels decreased significantly. PRL and cortisol also decreased, while single sample LH and FSH remained unchanged. There was a significant reduction in weight, which did not correlate with changes in serum testosterone levels. LH pulsatile release was not altered by training in the subset of 5 runners. These data confirm previous findings of physiological reduction in serum testosterone and PRL levels and suggest that the testosterone decrease is not related to changes in LH pulsatile release, weight, or increased serum cortisol levels.
横断面研究表明，一些男性运动员的总睾酮水平和生物可利用睾酮水平会降低。这种变化可能与体重减轻、血清皮质醇增加和/或促黄体生成素（LH）脉冲式释放改变有关。为了确定耐力训练如何影响雄激素水平，我们测量了15名以前久坐不动的男性的血清总睾酮、性激素结合球蛋白、游离雄激素指数、LH、促卵泡生成素（FSH）、催乳素（PRL）、皮质醇和体重。我们还检查了5名受试者亚组中的LH脉冲式释放情况。在6个月的训练期间，这些男性将每周跑步里程增加到平均每周56公里。总睾酮和游离雄激素指数水平显著下降。PRL和皮质醇也下降，而单次样本LH和FSH保持不变。体重显著减轻，这与血清睾酮水平的变化无关。在5名跑步者的亚组中，训练并未改变LH脉冲式释放。这些数据证实了先前关于血清睾酮和PRL水平生理性降低的研究结果，并表明睾酮降低与LH脉冲式释放、体重或血清皮质醇水平升高的变化无关。
