Zheng Yuan, Ye Dong-Qing, Pan Hai-Feng, Li Wen-Xian, Li Lian-Hong, Li Jing, Li Xiang-Pei, Xu Jian-Hua
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, People's Republic of China.
Clin Rheumatol. 2009 Mar;28(3):265-9. doi: 10.1007/s10067-008-1033-7. Epub 2008 Nov 11.
The objective of this study was to examine health-related quality of life (HRQOL) and social support in patients with systemic lupus erythematosus (SLE) and compare it with healthy people, to identify the relationship between social support and HRQOL in SLE patients, and to assess the influence of age, SLE Disease Activity Index (SLEDAI) and disease duration on HRQOL. We administered The Medical Outcomes Study Short Form-36 (MOS SF-36) questionnaire and the Social Support Rate Scale (SSRS) to a group of 202 patients with SLE and a healthy control group of 207 individuals. Spearman correlation was performed to identify the relationship between social support and HRQOL in SLE patients. The ordinal regression analyses were used to identify independent variables that were associated with the PCS and MCS. Results show that the physical (PCS) and mental (MCS) component summary scores of MOS SF-36 were lower in patients compared with healthy controls. Patients with SLE have a poorer social support as compared with healthy controls in subjective support, objective support, and availability of support. There was a positive correlation between social support and PCS and MCS. MCS and PCS were negatively associated with age and SLEDAI. MCS were negatively associated with disease duration. Taken together, this data suggested that patients with SLE have significant impairment of their HRQOL and less social support. HRQOL may be affected by social support, age, and SLEDAI.
本研究的目的是调查系统性红斑狼疮（SLE）患者的健康相关生活质量（HRQOL）和社会支持情况，并与健康人群进行比较，以确定SLE患者社会支持与HRQOL之间的关系，以及评估年龄、SLE疾病活动指数（SLEDAI）和病程对HRQOL的影响。我们对202例SLE患者和207名健康对照者进行了医学结局研究简明健康调查量表（MOS SF - 36）问卷和社会支持评定量表（SSRS）的测评。采用Spearman相关性分析确定SLE患者社会支持与HRQOL之间的关系。采用有序回归分析确定与生理健康综合评分（PCS）和心理健康综合评分（MCS）相关的独立变量。结果显示，与健康对照者相比，患者的MOS SF - 36生理健康综合评分（PCS）和心理健康综合评分（MCS）更低。与健康对照者相比，SLE患者在主观支持、客观支持和支持利用度方面的社会支持更差。社会支持与PCS和MCS呈正相关。MCS和PCS与年龄及SLEDAI呈负相关。MCS与病程呈负相关。综上所述，这些数据表明SLE患者的HRQOL有显著损害且社会支持较少。HRQOL可能受到社会支持、年龄和SLEDAI的影响。
