Department of Applied Biological Science, Tokyo Noko University, Saiwaicho 3-5-8, Fuchu, Tokyo, 183-8509, Japan.
Cytotechnology. 2003 Nov;43(1-3):155-9. doi: 10.1023/b:cyto.0000039903.22449.79.
In our previous study, resveratrol, a polyphenolic compound in grapes with antioxidative property, and resveratol-loaded rat serum (RS) were found to suppress the invasion of AH109A cells, an ascite hepatoma cell line. The aim of the present study was to investigate whether and which prostaglandins (PGs) would be involved in the invasion of AH109A cells and its suppression by resveratrol and resveratrol-loaded RS, using an in vitro invasion assay system. Not only PGE(2) but also PGF(2) (alpha) stimulated the spontaneous invasion of AH109A cells.They also canceled the resveratrol-induced suppression of hepatoma cell invasion. Results obtained suggest an involvement of PGs, especially PGE(2), in the invasion of hepatoma cells.
在我们之前的研究中，白藜芦醇，葡萄中的一种具有抗氧化特性的多酚化合物，以及负载白藜芦醇的大鼠血清（RS）被发现能够抑制腹水肝癌细胞系 AH109A 细胞的侵袭。本研究的目的是使用体外侵袭测定系统，探讨白藜芦醇和负载白藜芦醇的 RS 是否以及哪种前列腺素（PG）参与 AH109A 细胞的侵袭及其抑制。不仅 PGE（2），而且 PGF（2）（alpha）刺激 AH109A 细胞的自发侵袭。它们还取消了白藜芦醇诱导的肝癌细胞侵袭抑制。研究结果表明前列腺素，特别是 PGE（2），参与了肝癌细胞的侵袭。
