Kandel Rita, Roberts Sally, Urban Jill P G
CIHR-Bioengineering of Skeletal Tissues Team, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Eur Spine J. 2008 Dec;17 Suppl 4(Suppl 4):480-91. doi: 10.1007/s00586-008-0746-2. Epub 2008 Nov 13.
Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers' compensation benefits is significant. Surgical intervention as practised currently is directed towards removing the damaged or altered tissue. Development of new treatment modalities is critical as there is a growing consensus that the strategies used currently for symptomatic degenerative disc disease may not be effective. Accordingly, there is a need to develop an entirely new way to treat this disorder; regenerative medicine and tissue engineering approaches appear particularly promising in this regard. This paper reviews some of the challenges that currently are limiting the clinical application of this approach to the treatment of disc degeneration.
椎间盘退变是一种常见病症。尽管与之相关的背痛很少危及生命，但从发病率、生产力损失、医疗费用和工人补偿福利方面来看，每年的成本相当高昂。目前实施的手术干预旨在切除受损或改变的组织。由于越来越多的人认为目前用于症状性退行性椎间盘疾病的策略可能无效，因此开发新的治疗方法至关重要。因此，需要开发一种全新的方法来治疗这种疾病；在这方面，再生医学和组织工程方法显得特别有前景。本文综述了目前限制这种方法临床应用于治疗椎间盘退变的一些挑战。
