Mordasini Pasquale, Walser Amanda, Gralla Jan, Wiest Roland, Ozdoba Christoph, Reinert Michael, Schroth Gerhard
Institute of Diagnostic and Interventional Neuroradiology, University Hospital Inselspital, Berne, Switzerland.
Swiss Med Wkly. 2008 Nov 1;138(43-44):646-54. doi: 10.4414/smw.2008.12396.
To analyze the immediate and midterm angiographic and clinical results of stent placement in the endovascular treatment of intracranial cerebral aneurysms.
Out of 330 cerebral aneurysms treated by endovascular approach in our neurovascular centre, stents have been used in 18 patients. Twelve aneurysms (66.7%) were acutely ruptured, four (22.2%) were unruptured, two (11.1%) were recanalized after initial coiling. In three patients (16.7%) stent placement was used for revascularization of acute vessel thrombosis during coiling. Angiographic follow-up was obtained in 13 (72.2%) patients (mean 1.8 years, range 0.4-6.6) and clinical follow-up in 13 (72.2%) patients (mean 2.0 years, range 0.2-6.6).
Complete occlusion was achieved in eight (44.4%) patients, a neck-remnant remained in four (22.2%) and an incomplete occlusion in four (22.2%). In the two cases of previously treated aneurysms a neck-remnant remained after secondary stent-assisted coiling. In four cases thromboembolic events resulted in a transient procedure related morbidity. No permanent procedure related morbidity or mortality was observed. One case of an asymptomatic late in-stent stenosis occurred. On clinical followup modified Ranking Score was 0 in 3 patients (23.1%), 1 in 3 patients (23.1%) and 2-3 in 7 patients (53.9%). On angiographic follow-up recanalisation was observed in 5 (38.5% = 5/13) aneurysms.
Even in acutely ruptured aneurysms, stent assisted coiling can be a relatively effective and safe treatment for cerebral aneurysms. One asymptomatic in-stent stenosis occurred indicating that the risk rate of restenosis seems to be lower compared to stent deployment in atherosclerotic lesions, where restenosis rates up to 30% are described.
分析颅内脑动脉瘤血管内治疗中支架置入的即刻和中期血管造影及临床结果。
在我们神经血管中心采用血管内入路治疗的330例脑动脉瘤中,18例患者使用了支架。12例动脉瘤(66.7%)为急性破裂,4例(22.2%)未破裂,2例(11.1%)在初次弹簧圈栓塞后再通。3例患者(16.7%)在弹簧圈栓塞期间使用支架置入进行急性血管血栓形成的血管再通。13例患者(72.2%)进行了血管造影随访(平均1.8年,范围0.4 - 6.6年),13例患者(72.2%)进行了临床随访(平均2.0年,范围0.2 - 6.6年)。
8例患者(44.4%)实现完全闭塞,4例(22.2%)残留瘤颈,4例(22.2%)不完全闭塞。在2例先前治疗的动脉瘤病例中,二次支架辅助弹簧圈栓塞后残留瘤颈。4例血栓栓塞事件导致短暂的与手术相关的发病率。未观察到永久性的与手术相关的发病率或死亡率。发生1例无症状的晚期支架内狭窄。临床随访时,改良Rankin评分0分的有3例患者(23.1%),1分的有3例患者(23.1%),2 - 3分的有7例患者(53.9%)。血管造影随访时,13例动脉瘤中有5例(38.5% = 5/13)观察到再通。
即使对于急性破裂的动脉瘤,支架辅助弹簧圈栓塞对脑动脉瘤而言也可能是一种相对有效且安全的治疗方法。发生1例无症状的支架内狭窄,表明与在动脉粥样硬化病变中置入支架相比,再狭窄风险率似乎较低,动脉粥样硬化病变中的再狭窄率高达30%。