Haase Lori, Cerf-Ducastel Barbara, Murphy Claire
San Diego State University, University of California San Diego, San Diego, CA 92120-4913, USA.
Neuroimage. 2009 Feb 1;44(3):1008-21. doi: 10.1016/j.neuroimage.2008.09.044. Epub 2008 Oct 15.
This event-related functional magnetic resonance imaging (er-fMRI) study investigated BOLD signal change in response to a series of pure gustatory stimuli that varied in stimulus quality when subjects were hungry and sated with a nutritional pre-load. Group analyses showed significant differences in activation in the hunger minus satiety condition in response to sucrose, caffeine, saccharin, and citric acid within the thalamus, hippocampus, and parahippocampus. When examining the hunger and satiety conditions, activation varied as a function of stimulus, with the majority of the stimuli exhibiting significantly greater activation in the hunger state within the insula, thalamus, and substantia nigra, in contrast to decreased activation in the satiated state within the parahippocampus, hippocampus, amygdala, and anterior cingulate. Region of interest (ROI) analysis revealed two significant interactions, ROI by physiology and ROI by physiology by stimulus. In the satiety condition, the primary (inferior and superior insulae) and secondary (OFC 11 and OFC 47) taste regions exhibited significantly greater brain activation in response to all stimuli than regions involved in processing eating behavior (hypothalamus), affect (amygdala), and memory (hippocampus, parahippocampus and entorhinal cortex). These same regions demonstrated significantly greater activation within the hunger condition than the satiety condition, with the exception of the superior insula. Furthermore, the patterns of activation differed as a function taste stimulus, with greater activation in response to sucrose than to the other stimuli. These differential patterns of activation suggest that the physiological states of hunger and satiety produce divergent activation in multiple brain areas in response to different pure gustatory stimuli.
这项与事件相关的功能磁共振成像（er-fMRI）研究调查了在受试者饥饿和通过营养预负荷达到饱腹感时，对一系列味觉质量不同的纯味觉刺激做出反应时的血氧水平依赖（BOLD）信号变化。组分析显示，在丘脑、海马体和海马旁回中，饥饿减去饱腹感状态下，对蔗糖、咖啡因、糖精和柠檬酸的反应存在显著的激活差异。在检查饥饿和饱腹感状态时，激活情况随刺激而变化，大多数刺激在饥饿状态下在脑岛、丘脑和黑质中表现出显著更强的激活，相比之下，在饱腹状态下海马旁回、海马体、杏仁核和前扣带回中的激活则减少。感兴趣区域（ROI）分析揭示了两个显著的相互作用，即ROI与生理状态的相互作用以及ROI与生理状态和刺激的相互作用。在饱腹感状态下，初级（岛叶下部和上部）和次级（额下回11区和额下回47区）味觉区域对所有刺激的脑激活显著大于参与进食行为处理（下丘脑）、情感（杏仁核）和记忆（海马体、海马旁回和内嗅皮质）的区域。除了岛叶上部外，这些相同区域在饥饿状态下的激活显著大于饱腹感状态。此外，激活模式因味觉刺激而异，对蔗糖的反应比对其他刺激的激活更强。这些不同的激活模式表明，饥饿和饱腹感的生理状态在对不同的纯味觉刺激做出反应时，会在多个脑区产生不同的激活。
