Uttamchandani Mahesh, Neo Jia Ling, Ong Brandon Ngiap Zhung, Moochhala Shabbir
Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, 117510, Singapore.
Trends Biotechnol. 2009 Jan;27(1):53-61. doi: 10.1016/j.tibtech.2008.09.004. Epub 2008 Nov 12.
The microarray is a platform with wide-ranging potential in biodefence. Owing to the high level of throughput attainable through miniaturization, microarrays have accelerated the ability to respond in an epidemic or crisis. Extending beyond diagnostics, recent studies have applied microarrays as a research tool towards understanding the etiology and pathogenicity of dangerous pathogens, as well as in vaccine development. The original emphasis was on DNA microarrays, but the range now includes protein, antibody and carbohydrate microarrays, and research groups have exploited this diversity to further extend microarray applications in the area of biodefence. Here, we discuss the impact and contributions of the growing range of microarrays and emphasize the concepts that might shape the future of biodefence research.
微阵列在生物防御领域具有广泛的潜在应用价值。由于通过微缩化可实现高通量，微阵列加快了应对疫情或危机的能力。除诊断应用外，近期研究已将微阵列用作研究工具，以了解危险病原体的病因和致病性，以及用于疫苗研发。最初主要侧重于DNA微阵列，但现在其范围已涵盖蛋白质、抗体和碳水化合物微阵列，各研究团队利用这种多样性进一步拓展了微阵列在生物防御领域的应用。在此，我们探讨了微阵列种类不断增加所带来的影响和贡献，并强调了可能塑造生物防御研究未来的一些理念。
