嘘！微小RNA-155介导的基因沉默
Shhh! Silencing by microRNA-155.
作者信息
Teng Grace, Papavasiliou F Nina
机构信息
Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):631-7. doi: 10.1098/rstb.2008.0209.
Abstract
Small RNAs mediate a diverse pot-pourri of post-transcriptional silencing mechanisms, ranging from 'classical' RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeat-associated small RNAs. Here, we review recent findings on the function of miR-155, particularly its roles in mammalian innate and adaptive immunity, viral infection and oncogenesis.
摘要
小RNA介导了一系列多样的转录后沉默机制，从“经典”的RNA干扰（RNAi），到微小RNA（miRNA）介导的基因抑制，再到重复相关小RNA对基因组稳定性的维持。在此，我们综述了关于miR-155功能的最新研究发现，尤其是其在哺乳动物固有免疫和适应性免疫、病毒感染及肿瘤发生中的作用。
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