Allard Joanne S, Perez Evelyn, Zou Sige, de Cabo Rafael
Laboratory of Experimental Gerontology, National Institute on Aging, 6200 Seaforth Street, National Institutes of Health, Baltimore, MD 21224, USA.
Mol Cell Endocrinol. 2009 Feb 5;299(1):58-63. doi: 10.1016/j.mce.2008.10.018. Epub 2008 Nov 1.
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.
热量限制（CR）是一种非基因操作，可可靠地延长从酵母到狗等多种物种的寿命。CR的寿命延长效应与沉默信息调节因子2（Sir2）组蛋白脱乙酰酶及其哺乳动物同源物Sirt1的水平升高和激活密切相关。这种关联促使人们寻找潜在的激活Sirt1、延长寿命的分子。本文综述简要概述了白藜芦醇和其他Sirt1膳食激活剂的实验结果。
