Pipili Chrisoula, Sfritzeri Areti, Cholongitas Evangelos
Department of Internal Medicine, General Hospital of Sitia, GR-72300, Greece.
Eur J Intern Med. 2008 Nov;19(7):482-7. doi: 10.1016/j.ejim.2008.01.017. Epub 2008 Apr 1.
Systemic lupus erythematosus is an autoimmune and inflammatory disease characterized by a variety of symptoms, including arthropathy. The clinical presentation of joint involvement varies, ranging from arthralgia without erosions or deformity to an erosive arthropathy and severe functional disability. This paper reviews the main forms of deforming arthropathy observed in lupus patients. It includes a) non-erosive arthropathy (it is the most frequent form and characterized as Jaccoud's), b) erosive symmetrical polyarthritis with deformities similar to rheumatoid arthritis, named as rhupus, and c) mild deforming arthropathy. Even though enough such cases of patients have been reported in the international bibliography, no definite criteria for their diagnosis have been published yet. The use of contemporary radiological and immunological methods will facilitate their prevention and treatment.
系统性红斑狼疮是一种自身免疫性炎症性疾病,其特征为包括关节病在内的多种症状。关节受累的临床表现各不相同,从无侵蚀或畸形的关节痛到侵蚀性关节病和严重功能残疾。本文综述了狼疮患者中观察到的变形关节病的主要形式。它包括:a)非侵蚀性关节病(这是最常见的形式,特征为雅库关节病),b)具有类似于类风湿关节炎畸形的侵蚀性对称性多关节炎,称为rhupus,以及c)轻度变形关节病。尽管国际文献中已报道了足够多的此类患者病例,但尚未公布其明确的诊断标准。使用当代放射学和免疫学方法将有助于其预防和治疗。