Blandin S, David G
Service de pneumologie, centre hospitalier Plateau-d'Ouilly, BP 436, 69655 Villefranche-sur-Saône cedex, France.
Rev Pneumol Clin. 2008 Aug;64(4):202-10. doi: 10.1016/j.pneumo.2008.07.003. Epub 2008 Sep 19.
Aspergillus is involved in various lung illnesses related to type of exposition and immunity host response, local (tracheobronchial) and global. Allergic bronchopulmonary aspergillosis is due to a hypersensitivity response, diagnosis must be considered in presence of severe asthma with radiologic opacities, blood eosinophilia and elevated total serum IgE levels. Bronchial colonization is often accidentally discovered, but needs a monitoring. Pulmonary aspergilloma, often asymptomatic, grows in a preexisting cavity. Aspergillus bronchitis is a prolonged superficious endobronchial infection. Pseudomembranous necrotizing tracheobronchitis is a microinvasive bronchial infection, which prognosis is very bad. Acute invasive pulmonary aspergillosis affects quite always immunocompromised patients, but cases are not exceptional in patients with prior lung disease. Chronic necrotizing pulmonary aspergillosis may be divided in chronic cavitary and chronic fibrosing pulmonary aspergillosis, and subacute invasive aspergillosis according to the course of the disease, radiological outcome first. Management of diseases caused by Aspergillus is evolving with new diagnostic tools (PCR, Aspergillus antigenemia) and with new generation antifungal drugs.
曲霉与多种肺部疾病有关,这取决于暴露类型和宿主免疫反应,包括局部(气管支气管)和全身反应。变应性支气管肺曲霉病是由超敏反应引起的,在存在严重哮喘并伴有放射学阴影、血液嗜酸性粒细胞增多和血清总IgE水平升高时,必须考虑该病的诊断。支气管定植常为偶然发现,但需要进行监测。肺曲霉球通常无症状,在已有的空洞内生长。曲霉性支气管炎是一种迁延性浅表性支气管内感染。假膜性坏死性气管支气管炎是一种微侵袭性支气管感染,其预后很差。急性侵袭性肺曲霉病几乎总是累及免疫功能低下的患者,但在有既往肺部疾病的患者中也并不罕见。根据疾病进程,慢性坏死性肺曲霉病可分为慢性空洞性和慢性纤维化性肺曲霉病,以及亚急性侵袭性曲霉病,首先根据放射学结果进行分类。随着新的诊断工具(PCR、曲霉抗原血症)和新一代抗真菌药物的出现,曲霉所致疾病的治疗也在不断发展。