Barry Robert J, Clarke Adam R, McCarthy Rory, Selikowitz Mark, Brown Christopher R, Heaven Patrick C L
Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Northfields Avenue, Wollongong NSW 2522, Australia.
Int J Psychophysiol. 2009 Feb;71(2):124-31. doi: 10.1016/j.ijpsycho.2008.09.009. Epub 2008 Nov 5.
This study investigated whether ERPs from an inter-modal oddball task could distinguish between adults with Attention-Deficit/Hyperactivity Disorder (AD/HD) and controls. Two age-matched groups of young adult males (18 AD/HD, 18 controls) were presented with an inter-modal oddball task in which a counter-phasing checkerboard was the non-target visual stimulus (randomly presented on 80% of trials), and a 2000 Hz tone was the auditory target (20% of trials). Stimuli were presented at a fixed rate (stimulus-onset asynchrony 1.03 s) and participants were required to silently count all targets. The AD/HD group showed globally enhanced P2 and reduced N2 amplitudes to auditory targets, with no differences in target P3, together with topographic differences in N1 to auditory targets, and P1, N1, P2, N2 and P3 to visual non-targets, compared with controls. These results were interpreted in terms of early sensory-processing impairments in adults with AD/HD, which may be partially overcome through effortful processing, as reflected in the later endogenous ERP components.
本研究调查了来自多模态异常刺激任务的事件相关电位（ERP）是否能够区分患有注意力缺陷多动障碍（AD/HD）的成年人与对照组。两组年龄匹配的年轻成年男性（18名AD/HD患者，18名对照组）参与了一项多模态异常刺激任务，其中反相棋盘格为非目标视觉刺激（在80%的试验中随机呈现），2000赫兹的音调为听觉目标（20%的试验）。刺激以固定速率呈现（刺激起始异步时间为1.03秒），参与者需要默默数出所有目标。与对照组相比，AD/HD组对听觉目标的P2波幅整体增强，N2波幅降低，目标P3无差异，同时对听觉目标的N1以及对视觉非目标的P1、N1、P2、N2和P3存在地形差异。这些结果被解释为患有AD/HD的成年人存在早期感觉加工障碍，这种障碍可能通过后期内源性ERP成分所反映的努力加工得到部分克服。
