Colvin Bridget L, Matta Benjamin M, Thomson Angus W
Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, W1544 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Clin Lab Med. 2008 Sep;28(3):375-84, v. doi: 10.1016/j.cll.2008.07.003.
The role of dendritic cells (DC) in transplantation is often overshadowed by the more prominent roles of T and B cells, which interact directly with and, in the absence of immunosuppressive therapy, destroy the allograft. It has become increasingly recognized, however, that these potent antigen-presenting cells exert control over the immune response and regulate the balance between tolerance and immunity to transplanted organs and tissues. The role that chemokines play in influencing DC function with impact on regulation of immune responses against the graft is only beginning to be understood. This article considers how the manipulation of DC trafficking during an alloimmune response can affect graft outcome.
树突状细胞（DC）在移植中的作用常常被T细胞和B细胞更为显著的作用所掩盖，T细胞和B细胞可直接与同种异体移植物相互作用，并且在没有免疫抑制治疗的情况下会破坏该移植物。然而，人们越来越认识到，这些强大的抗原呈递细胞可控制免疫反应，并调节对移植器官和组织的耐受与免疫之间的平衡。趋化因子在影响DC功能从而对针对移植物的免疫反应调节产生影响方面所起的作用才刚刚开始被了解。本文探讨了在同种异体免疫反应期间对DC迁移的操控如何影响移植物的转归。
