评估多动症症状改善情况的测试的敏感性。
Sensitivity of tests to assess improvement in ADHD symptomatology.
作者信息
Grizenko Natalie, Lachance Martin, Collard Vincent, Lageix Philippe, Baron Chantal, Ben Amor Leila, Stepanian Marina Ter, Mbekou Valentin, Schwartz George, Bellingham Johanne, Joober Ridha
机构信息
Department of Psychiatry, McGill University.
出版信息
Can Child Adolesc Psychiatr Rev. 2004 May;13(2):36-9.
Abstract
OBJECTIVE
To assess which measurements best predict improvement on ADHD symptomatology after medication is given.
METHODS
147 children aged 6 to 12 years, diagnosed with ADHD, participated in a double-blind placebo controlled twoweek crossover trial of methylphenidate.
RESULTS
There were statistically significant differences on all measures between placebo and medication. Effect size for the overall group was 0.33 (CGI-P), 0.80 (CGI-T), 1.33 (CGI), 0.56 (CPT), 0.82 (RASS).
CONCLUSIONS
Acute behavioural response measures, where children are observed by clinicians (RASS and CGI), were overall more reliable than parent reports in detecting improvement on ADHD symptomatology. Teacher reports were also very important, especially in the 9 to 12 year old group.
摘要
目的
评估哪些测量方法最能预测用药后多动症症状的改善情况。
方法
147名年龄在6至12岁、被诊断患有多动症的儿童参与了一项为期两周的哌甲酯双盲安慰剂对照交叉试验。
结果
安慰剂组和用药组在所有测量指标上均存在统计学显著差异。整个组的效应量分别为：临床总体印象量表-改善情况（CGI-P）为0.33、临床总体印象量表-严重程度（CGI-T）为0.80、临床总体印象量表（CGI）为1.33、连续性能测试（CPT）为0.56、躁动行为评分量表（RASS）为0.82。
结论
在检测多动症症状改善方面，由临床医生观察儿童的急性行为反应测量方法（RASS和CGI）总体上比家长报告更可靠。教师报告也非常重要，尤其是在9至12岁组。
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