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荷兰关于结直肠手术后吻合口漏的内支架治疗的多中心经验。

The Dutch multicenter experience of the endo-sponge treatment for anastomotic leakage after colorectal surgery.

作者信息

van Koperen P J, van Berge Henegouwen M I, Rosman C, Bakker C M, Heres P, Slors J F M, Bemelman W A

机构信息

Department of Surgery, Academic Medical Center, P.O. Box 22660, 1100 A2, DD, Amsterdam, The Netherlands.

出版信息

Surg Endosc. 2009 Jun;23(6):1379-83. doi: 10.1007/s00464-008-0186-4. Epub 2008 Nov 27.

Abstract

BACKGROUND

Anastomotic leakage is a feared complication following colorectal surgery and is associated with early and long-term morbidity and mortality. The presacral cavity as the result of leakage can be treated with an endo-sponge (B-Braun Medical). The aim of this study was to assess the effectiveness of endo-sponge treatment of the presacral cavity as the result of anastomotic leakage in the Netherlands.

METHODS

Between July 2006 and April 2008, 16 patients (M/F = 9:7) with median age 64 years (range 19-78 years) who underwent surgery for rectal cancer (n = 13) or ulcerative colitis (n = 3) were treated with the endo-sponge treatment after anastomotic leakage.

RESULTS

Of the 16 patients, eight patients started with the endo-sponge treatment within 6 weeks after the initial surgery. In these patients the endo-sponge was placed after a median of 24 days (range 13-39 days) following surgery. In the remaining eight patients the endo-sponge treatment was started later than 6 weeks after the initial surgery. In this group there was a median of 74 days (range 43-1,602 days) between surgery and the start of endo-sponge placement. There was closure in six out of eight patients (75%) in the group that started with the endo-sponge treatment within 6 weeks of surgery compared with three out of eight patients (38%) in the group that started later (p = 0.315). Closure was achieved in a median of 40 (range 28-90) days with a median number of 13 sponge replacements (range 8-17).

CONCLUSIONS

Endo-sponge placement can be helpful in the treatment for anastomotic leakage after colorectal surgery and might prevent a chronic presacral sinus. However, it is not yet clear if this new treatment modality results in quicker healing.

摘要

背景

吻合口漏是结直肠手术后令人担忧的并发症,与早期和长期的发病率及死亡率相关。吻合口漏导致的骶前腔隙可用内塞棉条(贝朗医疗公司产品)治疗。本研究旨在评估荷兰使用内塞棉条治疗吻合口漏所致骶前腔隙的有效性。

方法

2006年7月至2008年4月,16例患者(男/女 = 9:7),中位年龄64岁(范围19 - 78岁),因直肠癌(n = 13)或溃疡性结肠炎(n = 3)接受手术,术后发生吻合口漏,接受内塞棉条治疗。

结果

16例患者中,8例在初次手术后6周内开始内塞棉条治疗。这些患者在手术后中位24天(范围13 - 39天)放置内塞棉条。其余8例患者在初次手术后6周后开始内塞棉条治疗。该组患者手术至开始放置内塞棉条的中位时间为74天(范围43 - 1602天)。手术6周内开始内塞棉条治疗的组中,8例患者有6例(75%)腔隙闭合,而6周后开始治疗的组中,8例患者有3例(38%)腔隙闭合(p = 0.315)。腔隙闭合的中位时间为40天(范围28 - 90天),内塞棉条更换的中位次数为13次(范围8 - 17次)。

结论

放置内塞棉条有助于治疗结直肠手术后的吻合口漏,并可能预防慢性骶前窦形成。然而,这种新的治疗方式是否能更快促进愈合尚不清楚。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ecd/2686802/5d74e1f90a09/464_2008_186_Fig1_HTML.jpg

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