苦瓜素F-S，来自苦瓜的葫芦烷三萜类化合物。
Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia.
作者信息
Chen Jian-Chao, Liu Wu-Qing, Lu Lu, Qiu Ming-Hua, Zheng Yong-Tang, Yang Liu-Meng, Zhang Xian-Min, Zhou Lin, Li Zhong-Rong
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
出版信息
Phytochemistry. 2009 Jan;70(1):133-40. doi: 10.1016/j.phytochem.2008.10.011. Epub 2008 Nov 29.
Chemical investigation of the vines and leaves of Momordica charantia resulted in isolation of fourteen cucurbitane triterpenoids, kuguacins F-S (1-14), including two pentanorcucurbitacins (6 and 7), one octanorcucurbitacin (8), and two trinorcucurbitacins (11 and 12), along with six known analogues. Their structures were elucidated on the basis of extensive spectroscopic and single-crystal X-ray diffraction analyses. Compounds 1-14 exhibited weak anti-HIV-1 activities in vitro.
对苦瓜的藤蔓和叶子进行化学研究，从中分离出14种葫芦烷三萜类化合物，即苦瓜素F - S（1 - 14），其中包括两种五环降葫芦素（6和7）、一种八环降葫芦素（8）以及两种三环降葫芦素（11和12），还有六种已知类似物。通过广泛的光谱分析和单晶X射线衍射分析确定了它们的结构。化合物1 - 14在体外表现出较弱的抗HIV - 1活性。
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