耳蜗微音器对哺乳动物耳极限频率的影响。
Effect of the cochlear microphonic on the limiting frequency of the mammalian ear.
作者信息
Iwasa Kuni H, Sul Bora
机构信息
Section on Biophysics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Ct Rm 1B03, Rockville, Maryland 20850-3211, USA.
出版信息
J Acoust Soc Am. 2008 Sep;124(3):1607-12. doi: 10.1121/1.2953317.
Electromotility is a basis for cochlear amplifier, which controls the sensitivity of the mammalian ear and contributes to its frequency selectivity. Because it is driven by the receptor potential, its frequency characteristics are determined by the low-pass RC filter intrinsic to the cell, which has a corner frequency about 1/10th of the operating frequency. This filter significantly decreases the efficiency of electromotility as an amplifier. The present paper examines a proposal that the cochlear microphonic, the voltage drop across the extracellular medium by the receptor current, contributes to overcome this problem. It is found that this effect can improve frequency dependence. However, this effect alone is too small to enhance the effectiveness of electromotility beyond 10 kHz in the mammalian ear.
电运动是耳蜗放大器的基础，它控制着哺乳动物耳朵的灵敏度并有助于其频率选择性。由于它由感受器电位驱动，其频率特性由细胞固有的低通RC滤波器决定，该滤波器的转折频率约为工作频率的十分之一。这种滤波器显著降低了电运动作为放大器的效率。本文研究了一种观点，即耳蜗微音器电位，也就是感受器电流在细胞外介质上产生的电压降，有助于克服这个问题。研究发现这种效应可以改善频率依赖性。然而，仅这种效应太小，无法在哺乳动物耳朵中使电运动在超过10千赫兹时增强有效性。
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