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在羊瘙痒病感染小鼠的脂肪组织中检测朊病毒传染性

Detection of prion infectivity in fat tissues of scrapie-infected mice.

作者信息

Race Brent, Meade-White Kimberly, Oldstone Michael B A, Race Richard, Chesebro Bruce

机构信息

Laboratory of Persistent Virus Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.

出版信息

PLoS Pathog. 2008 Dec;4(12):e1000232. doi: 10.1371/journal.ppat.1000232. Epub 2008 Dec 5.

DOI:10.1371/journal.ppat.1000232
PMID:19057664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2585054/
Abstract

Distribution of prion infectivity in organs and tissues is important in understanding prion disease pathogenesis and designing strategies to prevent prion infection in animals and humans. Transmission of prion disease from cattle to humans resulted in banning human consumption of ruminant nervous system and certain other tissues. In the present study, we surveyed tissue distribution of prion infectivity in mice with prion disease. We show for the first time detection of infectivity in white and brown fat. Since high amounts of ruminant fat are consumed by humans and also incorporated into animal feed, fat-containing tissues may pose a previously unappreciated hazard for spread of prion infection.

摘要

朊病毒感染性在器官和组织中的分布对于理解朊病毒病发病机制以及设计预防动物和人类朊病毒感染的策略至关重要。朊病毒病从牛传播给人类导致禁止人类食用反刍动物的神经系统和某些其他组织。在本研究中，我们调查了患有朊病毒病的小鼠体内朊病毒感染性的组织分布。我们首次在白色和棕色脂肪中检测到感染性。由于人类大量食用反刍动物脂肪，并且这些脂肪也被用于动物饲料中，含脂肪组织可能对朊病毒感染的传播构成了之前未被认识到的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/8f3d9bbda6a0/ppat.1000232.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/ef3e030da0c2/ppat.1000232.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/8c5006336050/ppat.1000232.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/ea27722e240c/ppat.1000232.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/8f3d9bbda6a0/ppat.1000232.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/ef3e030da0c2/ppat.1000232.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/8c5006336050/ppat.1000232.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/ea27722e240c/ppat.1000232.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8067/2585054/8f3d9bbda6a0/ppat.1000232.g004.jpg

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