Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Molecules. 2023 Feb 4;28(4):1521. doi: 10.3390/molecules28041521.
An investigation of the chemical composition of a Formosan soft coral sp. led to the discovery of one new verticillene-type diterpenoid, cespitulactam M (); one new eudesmane sesquiterpenoid, cespilamide F (); and three new hydroperoxysteroids (-) along with twelve known analogous metabolites (-). In addition, one new derivative, cespitulactam M-6,2'-diacetate (), was prepared from compound . The structures were determined by detailed spectroscopic analyses, particularly HRESIMS and NMR techniques. Moreover, the in vitro cytotoxicity, anti-inflammatory, and antibacterial activity of - and were evaluated.
对一种台湾产软珊瑚 sp. 的化学成分进行调查，发现了一种新的 verticillene 型二萜，cespitulactam M (); 一种新的桉烷倍半萜，cespilamide F (); 三种新的过氧甾醇 (-) 以及十二种已知类似代谢物 (-)。此外，还从化合物 制备了一种新的衍生物，cespitulactam M-6,2'-二乙酸酯 ()。结构通过详细的光谱分析，特别是 HRESIMS 和 NMR 技术确定。此外，还评估了 - 和 的体外细胞毒性、抗炎和抗菌活性。
