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来自台湾软珊瑚的生物活性二萜、降二萜和倍半萜

Bioactive Diterpenes, Norditerpenes, and Sesquiterpenes from a Formosan Soft Coral sp.

作者信息

Lin You-Cheng, Lin Chi-Chien, Chu Yi-Chia, Fu Chung-Wei, Sheu Jyh-Horng

机构信息

Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Institute of Biomedical Science, National Chung-Hsing University, Taichung 402, Taiwan.

出版信息

Pharmaceuticals (Basel). 2021 Dec 1;14(12):1252. doi: 10.3390/ph14121252.

DOI:10.3390/ph14121252
PMID:34959653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8708085/
Abstract

Chemical investigation of the soft coral sp. led to the discovery of twelve new verticillane-type diterpenes and norditerpenes: cespitulins H-O (-), one cyclic diterpenoidal amide cespitulactam L (), norditerpenes cespitulin P (), cespitulins Q and R ( and ), four new sesquiterpenes: cespilins A-C (-) and cespitulolide (), along with twelve known metabolites. The structures of these metabolites were established by extensive spectroscopic analyses, including 2D NMR experiments. Anti-inflammatory effects of the isolated compounds were studied by evaluating the suppression of pro-inflammatory protein tumor necrosis factor-α (TNF-α) and nitric oxide (NO) overproduction, and the inhibition of the gene expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in lipopolysaccharide-induced dendritic cells. A number of these metabolites were found to exhibit promising anti-inflammatory activities.

摘要

对软珊瑚物种进行的化学研究发现了12种新的轮状烷型二萜和去甲二萜：丛生素H - O（-）、一种环状二萜酰胺丛生内酰胺L（）、去甲二萜丛生素P（）、丛生素Q和R（和）、4种新的倍半萜：丛生素A - C（-）和丛生内酯（），以及12种已知代谢产物。这些代谢产物的结构通过广泛的光谱分析得以确定，包括二维核磁共振实验。通过评估在脂多糖诱导的树突状细胞中促炎蛋白肿瘤坏死因子-α（TNF-α）和一氧化氮（NO）过量产生的抑制情况，以及诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）基因表达的抑制情况，研究了分离出的化合物的抗炎作用。发现其中许多代谢产物具有有前景的抗炎活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/6a2719951f73/pharmaceuticals-14-01252-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/664392bf63a8/pharmaceuticals-14-01252-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/4428781c5eca/pharmaceuticals-14-01252-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/c92aae346383/pharmaceuticals-14-01252-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/5ba908631a66/pharmaceuticals-14-01252-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/4919207d98e4/pharmaceuticals-14-01252-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/105bc0c93aec/pharmaceuticals-14-01252-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/0168bb396b64/pharmaceuticals-14-01252-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/80d27d7cb5ed/pharmaceuticals-14-01252-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/a2400fd36f49/pharmaceuticals-14-01252-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/6a2719951f73/pharmaceuticals-14-01252-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/664392bf63a8/pharmaceuticals-14-01252-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/3f19b5aa857e/pharmaceuticals-14-01252-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/d005eedac855/pharmaceuticals-14-01252-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/9315dd0c4988/pharmaceuticals-14-01252-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/4428781c5eca/pharmaceuticals-14-01252-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/c92aae346383/pharmaceuticals-14-01252-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/5ba908631a66/pharmaceuticals-14-01252-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/4919207d98e4/pharmaceuticals-14-01252-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/105bc0c93aec/pharmaceuticals-14-01252-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/0168bb396b64/pharmaceuticals-14-01252-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/80d27d7cb5ed/pharmaceuticals-14-01252-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/a2400fd36f49/pharmaceuticals-14-01252-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f450/8708085/6a2719951f73/pharmaceuticals-14-01252-g013.jpg

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