路易斯酸催化通过分子内氧化还原过程形成四氢喹啉。
Lewis acid catalyzed formation of tetrahydroquinolines via an intramolecular redox process.
作者信息
Murarka Sandip, Zhang Chen, Konieczynska Marlena D, Seidel Daniel
机构信息
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
出版信息
Org Lett. 2009 Jan 1;11(1):129-32. doi: 10.1021/ol802519r.
PMID:19067554
Abstract
Polycyclic tetrahydroquinolines were prepared by an efficient Lewis acid catalyzed 1,5-hydride shift, ring closure sequence. Gadolinium triflate was identified as a catalyst that is superior to scandium triflate as well as other Lewis acids. An approach toward a catalytic enantioselective variant is also described.
摘要
通过高效的路易斯酸催化的1,5-氢迁移、环化序列制备了多环四氢喹啉。三氟甲磺酸钆被鉴定为一种优于三氟甲磺酸钪以及其他路易斯酸的催化剂。还描述了一种催化对映选择性变体的方法。
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