用于连续血糖监测的硼酸接枝无规共聚物传感液的研制
Development of boronic acid grafted random copolymer sensing fluid for continuous glucose monitoring.
作者信息
Li Siqi, Davis Erin N, Anderson Jordan, Lin Qiao, Wang Qian
机构信息
Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, Columbia, South Carolina 29208, USA.
出版信息
Biomacromolecules. 2009 Jan 12;10(1):113-8. doi: 10.1021/bm8009768.
Abstract
We have previously presented a microelectromechanical system (MEMS) based viscometric sensor for continuous glucose monitoring using protein Concanavalin A (Con A). To address its drawbacks, including immunotoxicity and instability issues, we have synthesized stable, biocompatible copolymers poly(acrylamide-ran-3-acrylamidophenylboronic acid) (PAA-ran-PAAPBA) for viscosity based glucose sensing. We found that PAA-ran-PAAPBA showed very high binding specificity to glucose. Several key factors such as polymer compositions, polymer molecular weights and polymer concentrations have been investigated to optimize viscometric responses. This polymer is able to detect glucose under physiological pH conditions in a reversible manner. Therefore, it has the potential to enable a highly reliable, continuous monitoring of glucose in subcutaneous tissue using the MEMS device.
摘要
我们之前展示了一种基于微机电系统（MEMS）的粘度传感器，该传感器使用伴刀豆球蛋白A（Con A）进行连续血糖监测。为了解决其缺点，包括免疫毒性和稳定性问题，我们合成了稳定的、生物相容性共聚物聚（丙烯酰胺-无规-3-丙烯酰胺基苯硼酸）（PAA-无规-PAAPBA）用于基于粘度的葡萄糖传感。我们发现PAA-无规-PAAPBA对葡萄糖表现出非常高的结合特异性。为了优化粘度响应，我们研究了几个关键因素，如聚合物组成、聚合物分子量和聚合物浓度。这种聚合物能够在生理pH条件下以可逆方式检测葡萄糖。因此，它有潜力使用MEMS设备实现对皮下组织中葡萄糖的高度可靠的连续监测。
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