Hollinghurst Sandra, Sharp Debbie, Ballard Kathleen, Barnett Jane, Beattie Angela, Evans Maggie, Lewith George, Middleton Karen, Oxford Frances, Webley Fran, Little Paul
Academic Unit of Primary Health Care, University of Bristol, Bristol BS8 2AA.
BMJ. 2008 Dec 11;337:a2656. doi: 10.1136/bmj.a2656.
An economic evaluation of therapeutic massage, exercise, and lessons in the Alexander technique for treating persistent back pain.
Cost consequences study and cost effectiveness analysis at 12 month follow-up of a factorial randomised controlled trial.
579 patients with chronic or recurrent low back pain recruited from primary care.
Normal care (control), massage, and six or 24 lessons in the Alexander technique. Half of each group were randomised to a prescription for exercise from a doctor plus behavioural counselling from a nurse.
Costs to the NHS and to participants. Comparison of costs with Roland-Morris disability score (number of activities impaired by pain), days in pain, and quality adjusted life years (QALYs). Comparison of NHS costs with QALY gain, using incremental cost effectiveness ratios and cost effectiveness acceptability curves.
Intervention costs ranged from pound30 for exercise prescription to pound596 for 24 lessons in Alexander technique plus exercise. Cost of health services ranged from pound50 for 24 lessons in Alexander technique to pound124 for exercise. Incremental cost effectiveness analysis of single therapies showed that exercise offered best value ( pound61 per point on disability score, pound9 per additional pain-free day, pound2847 per QALY gain). For two-stage therapy, six lessons in Alexander technique combined with exercise was the best value (additional pound64 per point on disability score, pound43 per additional pain-free day, pound5332 per QALY gain).
An exercise prescription and six lessons in Alexander technique alone were both more than 85% likely to be cost effective at values above pound20 000 per QALY, but the Alexander technique performed better than exercise on the full range of outcomes. A combination of six lessons in Alexander technique lessons followed by exercise was the most effective and cost effective option.
对治疗性按摩、运动以及亚历山大技术课程治疗持续性背痛进行经济学评估。
在一项析因随机对照试验的12个月随访中进行成本后果研究和成本效益分析。
从初级保健机构招募的579例慢性或复发性下背痛患者。
常规护理(对照)、按摩以及6节或24节亚历山大技术课程。每组中有一半患者被随机分配接受医生开具的运动处方以及护士提供的行为咨询。
英国国家医疗服务体系(NHS)和参与者的成本。将成本与罗兰-莫里斯残疾评分(因疼痛受损的活动数量)、疼痛天数以及质量调整生命年(QALY)进行比较。使用增量成本效益比和成本效益可接受性曲线,将NHS成本与QALY增益进行比较。
干预成本从运动处方的30英镑到24节亚历山大技术课程加运动的596英镑不等。卫生服务成本从24节亚历山大技术课程的50英镑到运动的124英镑不等。单一疗法的增量成本效益分析表明,运动提供了最佳价值(残疾评分每增加1分61英镑,每增加1个无疼痛天数9英镑,每获得1个QALY增益2847英镑)。对于两阶段疗法,6节亚历山大技术课程与运动相结合具有最佳价值(残疾评分每增加1分额外64英镑,每增加1个无疼痛天数43英镑,每获得1个QALY增益5332英镑)。
仅运动处方和6节亚历山大技术课程在每QALY价值高于20000英镑时,成本效益可能性均超过85%,但在所有结局指标方面,亚历山大技术的表现优于运动。6节亚历山大技术课程后再进行运动的组合是最有效且最具成本效益的选择。