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醋作为控制全口义齿佩戴者念珠菌属的抗菌剂。

Vinegar as an antimicrobial agent for control of Candida spp. in complete denture wearers.

作者信息

Pinto Telma Maria Silva, Neves Ana Christina Claro, Leão Mariella Vieira Pereira, Jorge Antonio Olavo Cardoso

机构信息

Department of Dentistry, University of Taubaté, Taubaté, SP, Brazil.

出版信息

J Appl Oral Sci. 2008 Nov-Dec;16(6):385-90. doi: 10.1590/s1678-77572008000600006.

Abstract

The use of denture is known to increase the carriage of Candida in healthy patients, and the proliferation of Candida albicans strains can be associated with denture-induced stomatitis. The aim of this study was to evaluate the use of vinegar as an antimicrobial agent for control of Candida spp. in complete upper denture wearers. Fifty-five patients were submitted to a detailed clinical interview and oral clinical examination, and were instructed to keep their dentures immersed in a 10% vinegar solution (pH less than 3) overnight for 45 days. Before and after the experimental period, saliva samples were collected for detection of Candida, counting of cfu/mL and identification of species by phenotypical tests (germ tube formation, chlamidoconidia production, and carbohydrate fermentation and assimilation). The results were analyzed using Spearman's correlation and Student's t-test (p<or=0.05). Candida yeasts were present in 87.3% of saliva samples before the treatment. A significant reduction was verified in CFU/mL counts of Candida after treatment. A positive correlation between Candida and denture stomatitis was verified, since the decrease of cfu/mL counts was correlated with a reduction in cases of denture stomatitis. Although it was not able to eliminate C. albicans, the immersion of the complete denture in 10% vinegar solution, during the night, reduced the amounts (cfu/mL) of Candida spp. in the saliva and the presence of denture stomatitis in the studied patients.

摘要

众所周知,佩戴假牙会增加健康患者口腔念珠菌的携带量,白色念珠菌菌株的增殖可能与假牙性口炎有关。本研究的目的是评估醋作为一种抗菌剂,用于控制全口上假牙佩戴者口腔念珠菌的效果。55名患者接受了详细的临床访谈和口腔临床检查,并被要求将假牙浸泡在10%的醋溶液(pH值小于3)中过夜,持续45天。在实验期前后,收集唾液样本用于检测念珠菌、计算每毫升菌落形成单位(cfu/mL)并通过表型试验(芽管形成、厚壁孢子产生以及碳水化合物发酵和同化)鉴定菌种。结果采用Spearman相关性分析和Student's t检验进行分析(p≤0.05)。治疗前,87.3%的唾液样本中存在念珠菌酵母。治疗后念珠菌的cfu/mL计数显著降低。念珠菌与假牙性口炎之间存在正相关,因为cfu/mL计数的降低与假牙性口炎病例的减少相关。尽管不能消除白色念珠菌,但夜间将全口假牙浸泡在10%的醋溶液中,可减少所研究患者唾液中念珠菌的数量(cfu/mL)以及假牙性口炎的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fae7/4327708/f2c8fd0c94b2/1678-7757-jaos-16-06-0385-gf01.jpg

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