Foley Paul Bernard
Prince of Wales Medical Research Institute, Randwick, NSW, Australia.
J Neural Transm (Vienna). 2009 Feb;116(2):143-50. doi: 10.1007/s00702-008-0161-1. Epub 2008 Dec 10.
An investigation of the characteristics of influenza epidemics in the nineteenth and early twentieth centuries was undertaken, principally in order to analyze the role of the 1918/1919 influenza pandemic in the etiology of encephalitis lethargica. Expectations regarding a future influenza pandemic derive principally from experiences in the 1918 epidemic. It is proposed that this pandemic was atypical with respect to many of its features, and that these have not been appropriately regarded in mapping expectations and responses of a future pandemic. Both a longer historical viewpoint (incorporating knowledge from all major nineteenth and twentieth century epidemics) and closer examination of individual epidemics at the town level is essential for producing an accurate picture of the challenge.
对19世纪和20世纪初流感流行特征进行了调查，主要目的是分析1918/1919年流感大流行在昏睡性脑炎病因学中的作用。对未来流感大流行的预期主要源于1918年疫情的经验。有人提出，这次大流行在许多特征方面是非典型的，而在规划未来大流行的预期和应对措施时，这些特征并未得到恰当考虑。要准确了解这一挑战，既需要从更长的历史视角（纳入19世纪和20世纪所有主要疫情的知识），也需要在城镇层面更仔细地审视个别疫情。
