von Bismarck Philipp, Claass Andreas, Schickor Carsten, Krause Martin F, Rose-John Stefan
Department of General Pediatrics, Universitatsklinikum Schleswig Holstein, Kiel, Germany.
Exp Lung Res. 2008 Dec;34(10):694-706. doi: 10.1080/01902140802389693.
Interleukin (IL)-6 signaling depends on the soluble IL-6 receptor (sIL-6R) and the soluble glycoprotein 130 (sgp130). To investigate the impact of IL-6 signaling on the pathogenesis of bronchopulmonary dysplasia of prematurity (BPD), IL-6, sIL-6R, and sgp130 were measured by enzyme-linked immunosorbent assay (ELISA) technique in tracheal aspirates of mechanically ventilated preterm infants. Infants developing BPD showed increased concentrations of IL-6, sIL-6R, and sgp-130 in their first week of life. These infants also had significantly higher molar ratios for IL-6/sIL-6R and IL-6/sgp130. The authors conclude that altered interleukin-6 signaling via the soluble receptors sIL-6R and sgp130 may play an important role in pulmonary inflammation of preterm infants.
白细胞介素（IL）-6信号传导依赖于可溶性IL-6受体（sIL-6R）和可溶性糖蛋白130（sgp130）。为了研究IL-6信号传导对早产儿支气管肺发育不良（BPD）发病机制的影响，采用酶联免疫吸附测定（ELISA）技术检测了机械通气早产儿气管吸出物中的IL-6、sIL-6R和sgp130。发生BPD的婴儿在出生后第一周时，其IL-6、sIL-6R和sgp-130的浓度升高。这些婴儿的IL-6/sIL-6R和IL-6/sgp130摩尔比也显著更高。作者得出结论，通过可溶性受体sIL-6R和sgp130改变白细胞介素-6信号传导可能在早产儿肺部炎症中起重要作用。
