氢化酶的小分子模拟物：氢化物与氧化还原
Small molecule mimics of hydrogenases: hydrides and redox.
作者信息
Gloaguen Frédéric, Rauchfuss Thomas B
机构信息
UMR CNRS 6521, Université de Bretagne Occidentale, CS 93837, 29238 Brest cedex 3, France.
出版信息
Chem Soc Rev. 2009 Jan;38(1):100-8. doi: 10.1039/b801796b. Epub 2008 Oct 31.
Abstract
This tutorial review is aimed at chemical scientists interested in understanding and exploiting the remarkable catalytic behavior of the hydrogenases. The key structural features are analyzed for the active sites of the two most important hydrogenases. Reactivity is emphasized, focusing on mechanism and catalysis. Through this analysis, gaps are identified in the synthesis of functional replicas of these fascinating and potentially useful enzymes.
摘要
本教程综述面向那些有兴趣了解和利用氢化酶卓越催化行为的化学科学家。对两种最重要的氢化酶的活性位点的关键结构特征进行了分析。强调了反应性，重点是机理和催化作用。通过这一分析，找出了在合成这些迷人且可能有用的酶的功能复制品方面存在的差距。
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