Scarpa Marco, Victor Charles J, O'Connor Brenda I, Cohen Zane, McLeod Robin S
Department of Surgery, Veneto Oncological Institute (IOV-IRCCS), Padova, Italy.
J Gastrointest Surg. 2009 Mar;13(3):416-22. doi: 10.1007/s11605-008-0775-5. Epub 2008 Dec 17.
Ileal pouch anal anastomosis (IPAA) is the procedure of choice for most patients requiring surgery for ulcerative colitis and familial adenomatous polyposis because of its perceived improvement in health-related quality of life (HRQL). The aims of this cross-sectional study were to validate an English version of the Padova Inflammatory Bowel Disease Quality of Life questionnaire (PIBDQL) in patients undergoing IPAA and to investigate the pre- and postoperative predictors of long-term HRQL.
In May 2005, the English version of the PIBDQL, Short Inflammatory Bowel Disease Questionnaire, and the SF-36 were mailed to 1,379 patients who underwent IPAA at the Mount Sinai Hospital between 1982 and 2004. The test-retest reliability, internal consistency, construct validity, and discriminative ability of the English version of the PIBDQL were assessed.
Nine hundred fifty-five patients (69%) (475 female, 480 male; mean, age 43 years) returned the questionnaires. The mean PIBDQL score was 21.1 (3.4), suggesting good quality of life. Test-retest reliability [intraclass correlation coefficient (ICC) = 0.784] and internal consistency (Cronbach's alpha = 0.83) were good. Construct validity and discriminative ability of the English version of PIBDQL were adequate. Multivariate analysis revealed that women (p < 0.01) and Crohn's disease patients (p < 0.01) had significantly worse PIBDQL scores.
The English version PIBDQL is a reliable and valid disease-specific instrument for assessing quality of life in patients with IPAA. In this series, female gender and CD were significant predictors of worse HRQL.
回肠袋肛管吻合术（IPAA）是大多数因溃疡性结肠炎和家族性腺瘤性息肉病而需要手术治疗的患者的首选术式，因为该术式被认为能改善健康相关生活质量（HRQL）。这项横断面研究的目的是在接受IPAA的患者中验证帕多瓦炎症性肠病生活质量问卷（PIBDQL）的英文版，并调查长期HRQL的术前和术后预测因素。
2005年5月，将PIBDQL英文版、简短炎症性肠病问卷和SF-36邮寄给1982年至2004年间在西奈山医院接受IPAA的1379名患者。评估了PIBDQL英文版的重测信度、内部一致性、结构效度和区分能力。
955名患者（69%）（475名女性，480名男性；平均年龄43岁）回复了问卷。PIBDQL平均得分为21.1（3.4），表明生活质量良好。重测信度[组内相关系数（ICC）=0.784]和内部一致性（Cronbach'sα=0.83）良好。PIBDQL英文版的结构效度和区分能力足够。多变量分析显示，女性（p<0.01）和克罗恩病患者（p<0.01）的PIBDQL得分明显更差。
PIBDQL英文版是一种可靠且有效的疾病特异性工具，用于评估IPAA患者的生活质量。在本系列研究中，女性性别和克罗恩病是HRQL较差的重要预测因素。
