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青蒿素的未来：天然的、合成的还是重组的？

The future of artemisinins: natural, synthetic or recombinant?

作者信息

Hommel Marcel

机构信息

Institut Pasteur, 25-28 rue du Dr Roux, Paris 75724 Cedex 15, France.

出版信息

J Biol. 2008 Dec 15;7(10):38. doi: 10.1186/jbiol101.

DOI:10.1186/jbiol101
PMID:19090980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2776395/
Abstract

Artemisinins are the most important anti-malarial drugs in use today, but are more costly than previous anti-malarials and production and price tend to fluctuate. Alternative ways of producing artemisinins are discussed here in the light of a recent paper in BMC Biotechnology on improving the yield of the precursor, artemisinic acid, in genetically engineered yeast.

摘要

青蒿素是目前使用的最重要的抗疟药物，但比以往的抗疟药物成本更高，而且产量和价格往往波动较大。本文根据《BMC生物技术》上最近一篇关于提高转基因酵母中前体青蒿酸产量的论文，讨论了生产青蒿素的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22dc/2776395/b22a72b696b3/jbiol101-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22dc/2776395/5d9b26d3e363/jbiol101-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22dc/2776395/b22a72b696b3/jbiol101-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22dc/2776395/5d9b26d3e363/jbiol101-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22dc/2776395/b22a72b696b3/jbiol101-2.jpg

相似文献

1
The future of artemisinins: natural, synthetic or recombinant?青蒿素的未来：天然的、合成的还是重组的？
J Biol. 2008 Dec 15;7(10):38. doi: 10.1186/jbiol101.
2
Production of the antimalarial drug precursor artemisinic acid in engineered yeast.在工程酵母中生产抗疟药物前体青蒿酸。
Nature. 2006 Apr 13;440(7086):940-3. doi: 10.1038/nature04640.
3
Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid.在经过基因工程改造以提高抗疟药物前体青蒿酸产量的酵母中诱导多个多药耐药基因。
BMC Biotechnol. 2008 Nov 4;8:83. doi: 10.1186/1472-6750-8-83.
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The malaria testing and treatment landscape in mainland Tanzania, 2016.2016年坦桑尼亚大陆的疟疾检测与治疗情况
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Artemisinins: activities and actions.青蒿素：活性与作用
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Malaria drug made in yeast causes market ferment.酵母合成的疟疾药物引发市场波动。
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Engineering yeast for industrial-level production of the antimalarial drug artemisinin.通过工程改造酵母实现抗疟药物青蒿素的工业化生产。
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引用本文的文献

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Antioxidants (Basel). 2020 Aug 14;9(8):753. doi: 10.3390/antiox9080753.
2
Assessment of Artemisinin Contents in Selected Species from Tajikistan (Central Asia).塔吉克斯坦（中亚）选定物种中青蒿素含量的评估。
Medicines (Basel). 2019 Jan 31;6(1):23. doi: 10.3390/medicines6010023.
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Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs.

本文引用的文献

1
Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity.不同疟疾流行程度地区的恶性疟原虫配子体动态
Malar J. 2008 Dec 3;7:249. doi: 10.1186/1475-2875-7-249.
2
Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid.在经过基因工程改造以提高抗疟药物前体青蒿酸产量的酵母中诱导多个多药耐药基因。
BMC Biotechnol. 2008 Nov 4;8:83. doi: 10.1186/1472-6750-8-83.
3
Artemisia annua as a self-reliant treatment for malaria in developing countries.
天然抗疟活性成分的优先级排序：具有体外抗疟活性的天然产物及当前注册的抗疟药物的化学信息学分析
Malar J. 2016 Jan 29;15:50. doi: 10.1186/s12936-016-1087-y.
4
A review of the effects of artemether-lumefantrine on gametocyte carriage and disease transmission.蒿甲醚-本芴醇对配子体携带及疾病传播影响的综述。
Malar J. 2014 Jul 28;13:291. doi: 10.1186/1475-2875-13-291.
5
Developing a yeast cell factory for the production of terpenoids.开发用于生产萜类化合物的酵母细胞工厂。
Comput Struct Biotechnol J. 2012 Nov 5;3:e201210006. doi: 10.5936/csbj.201210006. eCollection 2012.
6
Efficacy of artemether and artesunate in mice infected with praziquantel non-susceptible isolate of Schistosoma japonicum.青蒿琥酯和蒿甲醚对感染吡喹酮不敏感日本血吸虫分离株的小鼠的疗效。
Parasitol Res. 2014 Mar;113(3):925-31. doi: 10.1007/s00436-013-3724-5. Epub 2013 Dec 11.
7
Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum?双氢青蒿素对吡喹酮耐药日本血吸虫是否敏感性降低？
Parasitol Res. 2014 Jan;113(1):223-8. doi: 10.1007/s00436-013-3647-1. Epub 2013 Oct 22.
青蒿作为发展中国家治疗疟疾的一种自主疗法。
J Ethnopharmacol. 2008 Dec 8;120(3):302-14. doi: 10.1016/j.jep.2008.09.017. Epub 2008 Sep 27.
4
Predicting Global Fund grant disbursements for procurement of artemisinin-based combination therapies.预测全球基金用于采购青蒿素联合疗法的赠款支出。
Malar J. 2008 Oct 2;7:200. doi: 10.1186/1475-2875-7-200.
5
Artemisinins: their growing importance in medicine.青蒿素：它们在医学领域日益重要。
Trends Pharmacol Sci. 2008 Oct;29(10):520-7. doi: 10.1016/j.tips.2008.07.004. Epub 2008 Aug 25.
6
Qinghaosu (artemisinin): the price of success.青蒿素：成功的代价
Science. 2008 Apr 18;320(5874):330-4. doi: 10.1126/science.1155165.
7
Ensuring sustained ACT production and reliable artemisinin supply.确保青蒿素综合疗法药物的持续生产及可靠的青蒿素供应。
Malar J. 2007 Sep 15;6:125. doi: 10.1186/1475-2875-6-125.
8
Estimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs).在转向以青蒿素为基础的联合疗法（ACTs）之前估算非洲抗疟药物的消费量。
Malar J. 2007 Jul 10;6:91. doi: 10.1186/1475-2875-6-91.
9
Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes.三氧喹啉是新型抗疟药，对所有红细胞内期疟原虫包括配子体均有活性。
Antimicrob Agents Chemother. 2007 Apr;51(4):1463-72. doi: 10.1128/AAC.00967-06. Epub 2007 Jan 22.
10
Production of the antimalarial drug precursor artemisinic acid in engineered yeast.在工程酵母中生产抗疟药物前体青蒿酸。
Nature. 2006 Apr 13;440(7086):940-3. doi: 10.1038/nature04640.