Li Danjuan, Saito Reiko, Suzuki Yasushi, Sato Isamu, Zaraket Hassan, Dapat Clyde, Caperig-Dapat Isolde Ma, Suzuki Hiroshi
Department of Public Health, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.
J Clin Microbiol. 2009 Feb;47(2):466-8. doi: 10.1128/JCM.00892-08. Epub 2008 Dec 17.
No mutations were detected in the hemagglutinin gene of influenza A/H3N2 virus isolates from patients undergoing short-term amantadine treatment. However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells. Our results showed that only a few mutations were observed in MDCK-SIAT1-passaged isolates in the presence of amantadine.
在接受短期金刚烷胺治疗的患者所分离出的甲型H3N2流感病毒的血凝素基因中未检测到突变。然而,在MDCK或MDCK-SIAT1细胞中连续传代后发生了基因变化。我们的结果表明,在存在金刚烷胺的情况下,在MDCK-SIAT1传代分离株中仅观察到少数突变。