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PLoS Pathog. 2008 Aug 22;4(8):e1000133. doi: 10.1371/journal.ppat.1000133.
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MDCK-SIAT1 cells show improved isolation rates for recent human influenza viruses compared to conventional MDCK cells.与传统的MDCK细胞相比，MDCK-SIAT1细胞对近期人流感病毒的分离率更高。
J Clin Microbiol. 2008 Jul;46(7):2189-94. doi: 10.1128/JCM.00398-08. Epub 2008 May 14.
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High prevalence of amantadine-resistance influenza a (H3N2) in six prefectures, Japan, in the 2005-2006 season.2005 - 2006年季节，日本六个县金刚烷胺耐药甲型流感（H3N2）的高流行率。
J Med Virol. 2007 Oct;79(10):1569-76. doi: 10.1002/jmv.20946.
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Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity.通过具有改变的受体结合特异性的禽H5流感血凝素突变体进行免疫接种。
Science. 2007 Aug 10;317(5839):825-8. doi: 10.1126/science.1135165.
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The genesis and spread of reassortment human influenza A/H3N2 viruses conferring adamantane resistance.具有金刚烷抗性的重配人甲型H3N2流感病毒的起源与传播
Mol Biol Evol. 2007 Aug;24(8):1811-20. doi: 10.1093/molbev/msm103. Epub 2007 May 23.
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Amantadine-resistant influenza A (H3N2) virus in Japan, 2005-2006.2005 - 2006年日本的抗金刚烷胺甲型流感（H3N2）病毒
N Engl J Med. 2007 Jan 18;356(3):312-3. doi: 10.1056/NEJMc062989.
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Universal primer set for the full-length amplification of all influenza A viruses.用于甲型流感病毒全长扩增的通用引物组。
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Incidence of amantadine-resistant influenza A viruses in sentinel surveillance sites and nursing homes in Niigata, Japan.日本新潟地区哨点监测点及养老院中对金刚烷胺耐药的甲型流感病毒的发生率。
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甲型/ H3N2流感病毒M2和血凝素基因的体内和体外变化：在MDCK - SIAT1细胞和传统MDCK细胞中传代的影响

In vivo and in vitro alterations in influenza A/H3N2 virus M2 and hemagglutinin genes: effect of passage in MDCK-SIAT1 cells and conventional MDCK cells.

作者信息

Li Danjuan, Saito Reiko, Suzuki Yasushi, Sato Isamu, Zaraket Hassan, Dapat Clyde, Caperig-Dapat Isolde Ma, Suzuki Hiroshi

机构信息

Department of Public Health, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.

出版信息

J Clin Microbiol. 2009 Feb;47(2):466-8. doi: 10.1128/JCM.00892-08. Epub 2008 Dec 17.

DOI:10.1128/JCM.00892-08
PMID:19091815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2643669/
Abstract

No mutations were detected in the hemagglutinin gene of influenza A/H3N2 virus isolates from patients undergoing short-term amantadine treatment. However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells. Our results showed that only a few mutations were observed in MDCK-SIAT1-passaged isolates in the presence of amantadine.

摘要

在接受短期金刚烷胺治疗的患者所分离出的甲型H3N2流感病毒的血凝素基因中未检测到突变。然而，在MDCK或MDCK-SIAT1细胞中连续传代后发生了基因变化。我们的结果表明，在存在金刚烷胺的情况下，在MDCK-SIAT1传代分离株中仅观察到少数突变。