Nardone A, Anastassopoulou C G, Theeten H, Kriz B, Davidkin I, Thierfelder W, O'Flanagan D, Bruzzone B, Mossong J, Boot H J, Butur D, Slaciková M, Panait M L C, Hellenbrand W, DE Melker H, Sobotová Z, Icardi G, Andrews N, Pebody R G, VAN Damme P, Kafatos G, Miller E, Hatzakis A
Centre for Infections, Health Protection Agency, London, UK.
Epidemiol Infect. 2009 Jul;137(7):961-9. doi: 10.1017/S0950268808001672. Epub 2008 Dec 23.
To inform current and future vaccination strategies, we describe the seroepidemiology of hepatitis B virus (HBV) infection in ten representative European countries using standardized serology that allowed international comparisons. Between 1996 and 2003, national serum banks were compiled by collecting residual sera or by community sampling; sera were then tested by each country using its preferred enzyme immunoassays and testing algorithm, and assay results were standardized. Information on current and past HBV vaccination programmes in each country was also collected. Of the ten countries, six reported low levels (<3%) of antibodies against HBV core antigen (anti-HBc). Of the eight countries testing for HBV surface antigen (HBsAg), the highest prevalence was reported in Romania (5.6%) and in the remaining seven countries prevalence was <1%. Universal HBV vaccination programmes had been established in seven countries as recommended by the World Health Organization, but the seroprevalence of antibodies against HBsAg (anti-HBs) was lower than the reported vaccine coverage in three countries. Regular serological surveys to ascertain HBV status within a population, such as reported here, provide important data to assess the need for and to evaluate universal HBV vaccination programmes.
为指导当前及未来的疫苗接种策略，我们使用标准化血清学方法描述了十个有代表性的欧洲国家乙肝病毒（HBV）感染的血清流行病学情况，该方法允许进行国际比较。1996年至2003年期间，通过收集剩余血清或社区抽样建立了国家血清库；然后每个国家使用其首选的酶免疫测定法和检测算法对血清进行检测，并对检测结果进行标准化。还收集了每个国家当前和过去乙肝疫苗接种计划的信息。在这十个国家中，有六个国家报告乙肝核心抗原抗体（抗-HBc）水平较低（<3%）。在八个检测乙肝表面抗原（HBsAg）的国家中，罗马尼亚的患病率最高（5.6%），其余七个国家的患病率<1%。按照世界卫生组织的建议，七个国家已建立了普遍的乙肝疫苗接种计划，但在三个国家中，乙肝表面抗原抗体（抗-HBs）的血清阳性率低于报告的疫苗接种覆盖率。定期进行血清学调查以确定人群中的乙肝感染状况，如此处报告的那样，可为评估普遍乙肝疫苗接种计划的必要性和评估提供重要数据。
