Field J K, Spandidos D A, Malliri A, Gosney J R, Yiagnisis M, Stell P M
Department of Clinical Dental Sciences, University of Liverpool, UK.
Br J Cancer. 1991 Sep;64(3):573-7. doi: 10.1038/bjc.1991.352.
Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously treated or not, nor any of the clinico-pathological parameters. However a correlation was found between the patients smoking history and positive p53 staining. Six out of seven non-smokers did not express p53 whereas 29 of 37 heavy smokers were found to have elevated p53 expression (P less than 0.005). Also, of a group of ten patients who had given up smoking more than 5 years ago, nine had elevated expression. Epidemiological studies have shown a correlation between heavy smoking and head and neck cancer. The present study indicate a genetic link for this correlation.
使用两种p53抗体PAb 421和PAb 1801对头颈部鳞状细胞癌中的肿瘤抑制基因p53的表达进行了检测。在73例接受调查的患者中，67%发现p53表达升高。未发现p53表达与患者是否曾接受过治疗或任何临床病理参数相关。然而，发现患者的吸烟史与p53染色阳性之间存在相关性。7名不吸烟者中有6名未表达p53，而37名重度吸烟者中有29名被发现p53表达升高（P小于0.005）。此外，在一组10名5年前戒烟的患者中，有9名表达升高。流行病学研究表明重度吸烟与头颈部癌症之间存在相关性。本研究表明了这种相关性的遗传联系。
