Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Federal Atlixco-Metepec, 74360 Metepec, Puebla, Mexico.
Int J Infect Dis. 2009 Nov;13(6):690-5. doi: 10.1016/j.ijid.2008.10.010. Epub 2009 Jan 14.
To determine the prevalence of human papillomavirus (HPV) genotypes 6, 11, 16, 18, and 31 in Mexican women living in rural areas of Puebla, Mexico and to evaluate risk factors associated with cervical neoplasm in this population.
A cross-sectional study was conducted in 326 women at the General Hospital of Metepec, Puebla. Cervical samples were obtained using a cytobrush and tested for HPV genotypes by PCR assays using type-specific primers. A questionnaire was completed regarding gynecological, obstetric, and sexual behavior of the patients.
The overall prevalence of HPV infection was 25.4%, with two peaks of higher HPV prevalence in those aged 18-24 and 55-64 years. The individual genotype prevalences were: 9.6% HPV6, 4.8% HPV11, 54.2% HPV16, 37.3% HPV18, and 9.6% HPV31. Number of pregnancies was the most important risk factor associated with cervical cancer.
HPV16 was the most common type found in all cervical lesions. Genotype 16 or 18 was detected in patients with a diagnosis of cervical cancer. We found two peaks of age-specific HPV prevalence similar to findings reported worldwide.
确定墨西哥普埃布拉农村地区妇女中人类乳头瘤病毒（HPV）基因型 6、11、16、18 和 31 的流行情况，并评估该人群中与宫颈癌相关的危险因素。
在普埃布拉的梅特佩克综合医院对 326 名女性进行了一项横断面研究。使用细胞刷采集宫颈样本，并使用针对特定类型的引物通过聚合酶链反应（PCR）检测 HPV 基因型。针对患者的妇科、产科和性行为完成了一份调查问卷。
HPV 感染的总体流行率为 25.4%，18-24 岁和 55-64 岁的 HPV 流行率较高。个别基因型的流行率分别为：HPV6 9.6%、HPV11 4.8%、HPV16 54.2%、HPV18 37.3%和 HPV31 9.6%。怀孕次数是与宫颈癌最相关的重要危险因素。
HPV16 是所有宫颈病变中最常见的类型。在诊断为宫颈癌的患者中检测到了基因型 16 或 18。我们发现了两个与全球报告的发现相似的年龄特异性 HPV 流行高峰。
